Etiologic therapy of the hemorrhagic fever with nephritic syndrome

Abstract

At 20 patients with the hemorrhagic fever with nephritic syndrome the step technique of virazol therapy (intravenous introduction of 16 mg/kg 4 times day) within 3 days with the subsequent veroribavirin per os of (1000 mg day — 5 days) is applied. The beginning of therapy at all patients was in 4th-5th day of illness. At the patients receiving virazol, the body temperature was faster normalized, stomach pain disappeared, there was less oliguria duration, hemorrhagic syndrome was absent. Duration of RNA detection of hantavirus infection in blood of 20 patients receiving virazol and ribavirin, was less, than at patients not receiving antiviral medications. Positive influence of virazol on immuno-pathogenesis of the infections that is confirmed with the data of a cytokine level is found.