Antiviral activity of fukoidans of natural origin at the experimental infection caused by Hantavirus
Abstract
The virus inhibiting activity of the fukoidans of the brown seaweed in view of their structural features in experiences in vivo at hantavirus infection at mice is investigated. It is found, that fukoidans from brown seaweed Laminaria japonica and Laminaria cichorioides possess property to suppress the hantavirus infection to the peritoneal macrophages of mice mainly in an initial phase of infectious process. The positive effect of fukoidans from fukus and laminaria seaweed has been to some extent revealed for each of the tested preparations on 10, 14 and 21 st day. High antiviral activity of preparations in peak of an infection (10—14th day) is connected, with their immune modulating action.
About the Authors
I. G. Maksema
Scientific research institute of epidemiology and microbiology of the Siberian branch of the Russian Academy of Medical Science (Vladivostok)
Russian Federation
Russian Federation
I. D. Makarenkova
Scientific research institute of epidemiology and microbiology of the Siberian branch of the Russian Academy of Medical Science (Vladivostok)
Russian Federation
Russian Federation
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Review
For citations:
Maksema I.G., Makarenkova I.D. Antiviral activity of fukoidans of natural origin at the experimental infection caused by Hantavirus. Pacific Medical Journal. 2008;(2):86-89. (In Russ.)
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