Laser-induced nitric oxide action on microvasculature vessels reactivity
Abstract
Using vital microscopy method, the authors examined helium‑neon laser (0.63 µm and 2 mW) radiation response of mesostenium arterioles and venules, before and after applying the NOsynthase inhibitor L‑NAME, and after its activity being restored with L‑arginine. The laser radiation promoted blood flow acceleration in arterioles and venules and increase of their diameter. The value of arterial vessels dilatation inversely depended on their initial diameter. Precapillary arterioles were maximally sensitive to radiation. NO‑synthase inhibition reduced the laser effect on arterioles in half; the laser effect on venules decreased 3–8%, only. The introduction of L‑arginine promoted partial restoration of vessel reactivity.
About the Authors
A. E. Kotsuba
Vladivostok State Medical University
Russian Federation
Russian Federation
E. P. Bespalova
Vladivostok State Medical University
Russian Federation
Russian Federation
V. M. Chertok
Vladivostok State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Kotsuba A.E., Bespalova E.P., Chertok V.M. Laser-induced nitric oxide action on microvasculature vessels reactivity. Pacific Medical Journal. 2007;(4):44-46. (In Russ.)
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