Subpopulation structure of the lymphocytes of the umbilical blood of newborns and prospects of its use as the predictor of atopic diseases at children
Abstract
153 in term newborns underwent the analysis on immune parameters of the umbilical blood and questioning of mothers about the allergic anamnesis. The results of research show the stimulation of immune system of the child by infectious factors in the intra‑uterine period. These facts correlate to the “hygienic hypothesis” about a protective role of mild infectious diseases in the atopic illnesses through the stimulation of the Th1 of immunity and high production of the γ‑interferon.
About the Authors
S. Yu. Tereshchenko
Scientific research institute of medical problems of the North of the Siberian branch of the Russian Academy of Medical Science;
Krasnoyarsk regional center of AIDS and infectious diseases prophylaxis;
Krasnoyarsk state medical academy
Russian Federation
Russian Federation
V. I. Prohorenkov
Scientific research institute of medical problems of the North of the Siberian branch of the Russian Academy of Medical Science;
Krasnoyarsk regional center of AIDS and infectious diseases prophylaxis;
Krasnoyarsk state medical academy
Russian Federation
Russian Federation
I. A. Novitsky
Scientific research institute of medical problems of the North of the Siberian branch of the Russian Academy of Medical Science;
Krasnoyarsk regional center of AIDS and infectious diseases prophylaxis;
Krasnoyarsk state medical academy
Russian Federation
Russian Federation
I. A. Ol’hovsky
Scientific research institute of medical problems of the North of the Siberian branch of the Russian Academy of Medical Science;
Krasnoyarsk regional center of AIDS and infectious diseases prophylaxis;
Krasnoyarsk state medical academy
Russian Federation
Russian Federation
N. A. Shakina
Scientific research institute of medical problems of the North of the Siberian branch of the Russian Academy of Medical Science;
Krasnoyarsk regional center of AIDS and infectious diseases prophylaxis;
Krasnoyarsk state medical academy
Russian Federation
Russian Federation
I. V. Isakov
Scientific research institute of medical problems of the North of the Siberian branch of the Russian Academy of Medical Science;
Krasnoyarsk regional center of AIDS and infectious diseases prophylaxis;
Krasnoyarsk state medical academy
Russian Federation
Russian Federation
L. V. Vasil’eva
Scientific research institute of medical problems of the North of the Siberian branch of the Russian Academy of Medical Science;
Krasnoyarsk regional center of AIDS and infectious diseases prophylaxis;
Krasnoyarsk state medical academy
Russian Federation
Russian Federation
E. G. Neyman
Scientific research institute of medical problems of the North of the Siberian branch of the Russian Academy of Medical Science;
Krasnoyarsk regional center of AIDS and infectious diseases prophylaxis;
Krasnoyarsk state medical academy
Russian Federation
Russian Federation
References
1. Gabrielsson S., Soderlund A., Nilsson C. et al. // Clin. Exp. Immunol. – 2001. – Vol. 126, No. 3. – P. 390–396.
2. Hagendorens M.M., Ebo D.G., Schuerwegh A.J. et al. // Clin. Exp. Allergy. – 2003. – Vol. 33, No. 5. – P. 633–639.
3. Hsieh F.H., Lam B.K., Penrose J.F. et al. // J. Exp. Med. – 2001. – Vol. 193, No. 1. – P. 123–133.
4. Kopp M.V., Zehle C., Pichler J. et al. // Clin. Exp. Allergy. – 2001. – Vol. 31, No. 10. – P. 1536–1543.
5. Nilsson C., Larsson A.K., Hoglind A. et al. // Clin. Exp. Allergy. – 2004. – Vol. 34, No. 3. – P. 373–380.
6. Romagnani S., Parronchi P., D’elios M.M. et al. // Int. Arch. Allergy Immunol. – 1997. – Vol. 113, No. 1–3. – P. 153–156.
7. Schade R.P., Van Ieperen-Van Dijk A.G., Versluis C. et al. // J. Allergy Immunol. – 2002. – Vol. 109, No. 2. – P. 357–362.
8. Yamamoto J., Adachi Y., Onoue Y. et al. // Allergy. – 2000. – Vol. 55, No. 11. – P. 1011–1018.
Review
For citations:
Tereshchenko S.Yu., Prohorenkov V.I., Novitsky I.A., Ol’hovsky I.A., Shakina N.A., Isakov I.V., Vasil’eva L.V., Neyman E.G. Subpopulation structure of the lymphocytes of the umbilical blood of newborns and prospects of its use as the predictor of atopic diseases at children. Pacific Medical Journal. 2007;(3):41-43. (In Russ.)
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