Immune efficiency of the polycomponental pneumococcal vaccine at children with respiratory diseases
Abstract
The clinical and immunologic influence of use of the “Pneumo‑23” vaccine (France) at 42 children with bronchial asthma after pneumonias is done. Statistically authentic increase in specific antibodies (IgМ and IgG) as to the poly‑saccharide complex of the vaccine, and also to Т3, В6, 9N‑serotypes of the S. pneumoniae is revealed, that testifies the specific post‑vaccinal immunity. Decrease in local level of the interleukin‑8 and respiratory inflammation severity is found. Safety and immune efficiency of vaccination of children with the respiratory diseases is shown.
About the Authors
E. V. Markelova
Vladivostok state medical universit;
Far East branch of scientific research institute of clinical mmunology of the Siberian branch of the Russian Academy of Medical Science;
Scientific research vaccines institute named by I.I. Mechnikov
Russian Federation
Russian Federation
Vladivostok;
Moscow
Ya. S. Guschina
Vladivostok state medical universit;
Far East branch of scientific research institute of clinical mmunology of the Siberian branch of the Russian Academy of Medical Science;
Scientific research vaccines institute named by I.I. Mechnikov
Russian Federation
Russian Federation
Vladivostok;
Moscow
M. P. Kostinov
Vladivostok state medical universit;
Far East branch of scientific research institute of clinical mmunology of the Siberian branch of the Russian Academy of Medical Science;
Scientific research vaccines institute named by I.I. Mechnikov
Russian Federation
Russian Federation
Vladivostok;
Moscow
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Review
For citations:
Markelova E.V., Guschina Ya.S., Kostinov M.P. Immune efficiency of the polycomponental pneumococcal vaccine at children with respiratory diseases. Pacific Medical Journal. 2007;(3):71-74. (In Russ.)
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