THE ROLE OF CYTOKINES IN THE DEVELOPMENT OF THE PNEUMONIA AFTER AORTO-CORONARY BYPASS AT PATIENTS WITH ISCHEMIC HEART DISEASE
Abstract
Authors estimated the role of the antiinflammatory cytokine IL-10 and regulator cytokine IL-12 in the development of pneumonia in 53 patients after aorto-coronary bypass. In the patients with a postoperative pneumonia the increased blood level of IL-10 before the surgery, and in 1 day after surgery the decrease in the ratio IL-12p70/IL-12p40 and excessive growth of secretion of IL-10 is revealed, and also the decrease in the mitogen-activated secretion of IL-10 by blood cells and the decrease in the index of activation of cells to IL-12 production is found. The revealed abnormalities determine the necessity of immunotrope therapy to this category of patients.
About the Authors
E. V. Markelova
Vladivostok State Medical University; Primorsky Regional Hospital No. 1; Far Eastern Branch of Scientific Research Institute Clinical Research Siberian Branch of the Russian Academy of Medical Sciences; The Branch of Scientific Research Institute of Cardiology of the Tomsk Scientific Centre Siberian Branch of the Russian Academy of Medical Sciences (Vladivostok)
Russian Federation
Russian Federation
E. P. Turmova
Vladivostok State Medical University; Primorsky Regional Hospital No. 1; Far Eastern Branch of Scientific Research Institute Clinical Research Siberian Branch of the Russian Academy of Medical Sciences; The Branch of Scientific Research Institute of Cardiology of the Tomsk Scientific Centre Siberian Branch of the Russian Academy of Medical Sciences (Vladivostok)
Russian Federation
Russian Federation
A. A. Silaev
Vladivostok State Medical University; Primorsky Regional Hospital No. 1; Far Eastern Branch of Scientific Research Institute Clinical Research Siberian Branch of the Russian Academy of Medical Sciences; The Branch of Scientific Research Institute of Cardiology of the Tomsk Scientific Centre Siberian Branch of the Russian Academy of Medical Sciences (Vladivostok)
Russian Federation
Russian Federation
D. B. Andreev
Vladivostok State Medical University; Primorsky Regional Hospital No. 1; Far Eastern Branch of Scientific Research Institute Clinical Research Siberian Branch of the Russian Academy of Medical Sciences; The Branch of Scientific Research Institute of Cardiology of the Tomsk Scientific Centre Siberian Branch of the Russian Academy of Medical Sciences (Vladivostok)
Russian Federation
Russian Federation
V. V. Volkov
Vladivostok State Medical University; Primorsky Regional Hospital No. 1; Far Eastern Branch of Scientific Research Institute Clinical Research Siberian Branch of the Russian Academy of Medical Sciences; The Branch of Scientific Research Institute of Cardiology of the Tomsk Scientific Centre Siberian Branch of the Russian Academy of Medical Sciences (Vladivostok)
Russian Federation
Russian Federation
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Review
For citations:
Markelova E.V., Turmova E.P., Silaev A.A., Andreev D.B., Volkov V.V. THE ROLE OF CYTOKINES IN THE DEVELOPMENT OF THE PNEUMONIA AFTER AORTO-CORONARY BYPASS AT PATIENTS WITH ISCHEMIC HEART DISEASE. Pacific Medical Journal. 2006;(2):35-37. (In Russ.)
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