The possibility of using tantalum oxide microparticles in phosphate glass for radiation therapy of malignant neoplasms
https://doi.org/10.34215/1609-1175-2020-4-85-87
Abstract
Objective: The creation of the medicine for a local radiomodification of tumors.
Methods: The level of the secondary radiation on the surface of the phosphate glass powder with the inclusion of tantalum oxide processed by 6 MeV deceleration emission was studied. Medical linear accelerator TrueBeam (Varian, USA), and Semiconductor diode detector PDI 2.0 (Sun Nuclear Corp., USA) having the system of moving in vertical plane and the system of position video recording were used.
Results: The presence of the phosphate glass (containing 20% Та2О5) on the surface gave a 63.7% increase to the secondary radiation. It’s around two thirds of the overall level.
Conclusion: An opportunity to create a medicine on the basis of phosphate glass, containing tantalum oxide, for local radiomodification of malignant tumors.
About the Authors
O. S. Plotnikova
Pacific State Medical University;
Primorskiy Regional Oncological Dispensary
Russian Federation
Russian Federation
MD, radiologist;
graduate student, 2 Ostryakova Ave., 690002, Vladivostok
V. I. Apanasevich
Pacific State Medical University;
Primorskiy Regional Oncological Dispensary
Russian Federation
Russian Federation
MD, PhD, professor, Institute of Surgery,
2 Ostryakova Ave., Vladivostok, 690002
M. A. Medkov
Institute of Chemistry, Far East Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
PhD,
159 Stoletiya Vladivostoka Ave., Vladivostok, 690022
A. A. Polezhaev
Pacific State Medical University
Russian Federation
Russian Federation
MD, PhD, professor of the Surgery Institute,
2 Ostryakova Ave., Vladivostok, 690002
V. I. Nevozhai
Pacific State Medical University
Russian Federation
Russian Federation
MD, PhD, professor of the Institute of Surgery,
2 Ostryakova Ave., Vladivostok, 690002
O. A. Argishev
Primorskiy Regional Oncological Dispensary
Russian Federation
Russian Federation
MD, head of the Department of Breast Tumors,
57a Russkaya St., Vladivostok, 690069
References
1. Kaprin AD, Starinsky VV, Petrova GV, eds. The status of cancer care for the population of Russia in 2018. Moscow: P. Hertsen Moscow Oncology Research Institute; 2019 (In Russ).
2. Lukyanenko KS, Apanasevich VI, Lagureva AV, Plotnikova OS, Pankratov IV, Rudyuk VP, et al. The possibility of generating secondary ionizing radiation on tantalum oxide nanoparticles during radiation therapy of malignant neoplasms. Pacific Medical Journal. 2016;4:38–9 (In Russ).
3. Joyner MS, van der Kogel OJ, eds. The basics of clinical radiobiology. Moscow: BINOM; 2014 (In Russ).
4. Narkevich BYa, ed. Clinical dosimetry. Physicotechnical basis. Moscow: N.N. Blokhin Russian Cancer Research Center; 2019 (In Russ).
5. Wieser ME, Holden N, Coplen TB, Böhlke JK, Berglund M, Brand WA, et al. Atomic weights of the elements 2011 (IUPAC Technical Report). Pure and Applied Chemistry. 2013;85(5)1047–78.
6. Polkovnikova AS, Lukyanenko KS, Lagureva AV, Plotnikova OS, Elimination of radio modifiers based on tantalum nanoparticles from tissues. Materials of the regional scientific-practical conference of students, graduate students and young scientists in the natural sciences. Vladivostok; 2016:561–2 (In Russ).
7. Bourien H, Palard X, Rolland Y, Le Du F, Beuzit L, Uguen T, et al. Yttrium-90 glass microspheres radioembolization (RE) for biliary tract cancer: A large single-center experience. Eur J Nucl Med Mol Imaging. 2019;46:669–76.
8. Hickey R, Lewandowski RJ, Prudhomme T, Ehrenwald E, Baigorri B, Critchfield J, et al. 90Y radioembolization of colorectal hepatic metastases using glass microspheres: Safety and survival outcomes from a 531-patient multicenter study. J Nucl Med. 2016;57(5):665–71.
9. Zhang Y, Wang X, Su Y, Chen D, Zhong W. A doxorubicin delivery system: Samarium/mesoporous bioactive glass/alginate composite microspheres. Mater Sci Eng: C. 2016; 67:205–13.
Review
For citations:
Plotnikova O.S., Apanasevich V.I., Medkov M.A., Polezhaev A.A., Nevozhai V.I., Argishev O.A. The possibility of using tantalum oxide microparticles in phosphate glass for radiation therapy of malignant neoplasms. Pacific Medical Journal. 2020;(4):85-87. (In Russ.) https://doi.org/10.34215/1609-1175-2020-4-85-87
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