Polymorphic variant of the IFNG-gene and the level of antigen-specific production of interferon-Y among children
https://doi.org/10.34215/1609-1175-2021-1-28-33
Abstract
Objective: The assessment of the level of interferon-у (IFN-y) production after stimulation by specific antigens in case of a polymorphic variation of (T-1488C) IFNG gen among children.
Methods: From 2014 to 2018 prospective cross-sectional study of 160 children under 18 years old was conducted. 81 of them had tuberculosis, 72 - latent tuberculosis infection and 16 - non-infected.
Results: It was determined that polymorphic variation of (T-1488C) IFNG gen is connected with tuberculosis and its heterozygous genotype can be considered as a marker of a high risk of a disease.
Conclusions: Polymorphic variation of (T-1488C) IFNG gen is associated with the different level of immune response against separate specific antigens - according to the assessment of the level of induced IFN-y which decreased in case of heterozygous and homozygous genotype for an allele C. The existence of homozygous genotype for an allele T was associated with the high level of IFN-y production after specific stimulation among the children having latent tuberculosis infection.
About the Authors
M. A. Plekhanova
Moscow Regional Clinical Tuberculosis Dispensary
Russian Federation
Russian Federation
Maria A. Plekhanova, MD, PhD, associate professor.
11/1 Borby Sq., Moscow, 127055
A. P. Tkachuk
Federal Research Center of N.F. Gamalei of Epidemiology and Microbiology
Russian Federation
Russian Federation
Artem P. Tkachuk, PhD, leading researcher, head of the Translational Biomedicine Laboratory of the Department of Genetics and Molecular Biology of Bacteria.
18 Gamalei St., Moscow, 123098
U. I. Patsula
Оmsk Research Institute of Natural Focal Infections
Russian Federation
Russian Federation
Uriy I. Patsula, PhD, senior researcher.
7 Mira Ave., Omsk, 644080
S. V. Smerdin
Moscow Regional Clinical Tuberculosis Dispensary
Russian Federation
Russian Federation
Sergey V. Smerdin, MD, PhD, professor, chief physician.
11/1 Borby Sq., Moscow, 127055
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Review
For citations:
Plekhanova M.A., Tkachuk A.P., Patsula U.I., Smerdin S.V. Polymorphic variant of the IFNG-gene and the level of antigen-specific production of interferon-Y among children. Pacific Medical Journal. 2021;(1):28-33. (In Russ.) https://doi.org/10.34215/1609-1175-2021-1-28-33
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