Prognostic factors of the efficiency of valve bronchial block in patients having destructive tuberculosis and low motivation for treatment
https://doi.org/10.34215/1609-1175-2021-1-46-50
Abstract
Objective: To estimate factors influencing healing of the pulmonary tumor cavitation in case of valve bronchial block (VBB) among patients having tuberculosis and low motivation to take anti-tuberculosis medicines.
Methods: 135 patients having destructive tuberculosis and low motivation for treatment were studied according to factors influencing the effectiveness of VBB. Depending on the results two groups of patients were defined: patients with healing (n=78) and patients whose pulmonary tumor cavitation stayed at the same level (n = 56).
Results: The method turned out to be the most effective for patients having the duration of the disease for less than 2 years, upper-lobe localization of tuberculosis process with the pulmonary tumor cavitation up to 2 cm, bacteriologically proven, having HIV co-infection with the concentration of CD4+-lymphocytes in blood in the amount of more than 250 cells per microliter and committed to antiretroviral therapy and also among patients with the periodic anti-tuberculosis chemotherapy take offs after treatment restarting.
Conclusions: Such factors as tuberculosis anamnesis for longer than 2 years, 4-7 cm cavitation, remaining mild or abundant bacterioexcretion, wide drug resistance of the pathogen, the level of CD4+-lymphocytes in blood less than 250 cells per microliter for HIV co-infected, and total rejection of anti-tuberculosis drugs influence the maintaining of the destructive changes on the basis of VBB.
About the Authors
P. A. Fadeev
Zabaykalskiy Regional Clinical Phthisiopulmonary Center
Russian Federation
Russian Federation
Pavel A. Fadeev, MD, chief freelance TB specialist of the Far Eastern Federal District, chief physician.
3 Taezhnaya St., Chita, 672038
D. V. Krasnov
Novosibirsk State Medical University
Russian Federation
Russian Federation
Denis V. Krasnov, MD, PhD, associate professor, Department of Tuberculosis FAT and PRD.
52 Krasnyi Ave., Novosibirsk, 630091
V. A. Krasnov
Novosibirsk State Medical University
Russian Federation
Russian Federation
Vladimir A. Krasnov, MD, PhD, professor, head of the Department of Tuberculosis FAT and PRD.
52 Krasnyi Ave., Novosibirsk, 630091
Ya. K. Petrova
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Yana K. Petrova, MD, PhD.
81a Okhotskaya St., Novosibirsk, 630040
S. V. Skluev
Novosibirsk State Medical University; Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Sergey V. Skluev, MD, PhD, head of the Endoscopy Department.
81a Okhotskaya St., Novosibirsk, 630040
N. G. Grishenko
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Nikolay G. Grischenko, MD, PhD, chief researcher.
81a Okhotskaya St., Novosibirsk, 630040
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Review
For citations:
Fadeev P.A., Krasnov D.V., Krasnov V.A., Petrova Ya.K., Skluev S.V., Grishenko N.G. Prognostic factors of the efficiency of valve bronchial block in patients having destructive tuberculosis and low motivation for treatment. Pacific Medical Journal. 2021;(1):46-50. (In Russ.) https://doi.org/10.34215/1609-1175-2021-1-46-50
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