Ectopic taste buds TAS2R31 in blood serum in different types of bronchial asthma
https://doi.org/10.34215/1609-1175-2021-1-68-71
Abstract
Objective: To estimate the expression level of bitter taste buds TAS2R31 in blood serum in different variations of bronchial asthma (BA).
Methods: 10 practically healthy people and 51 patients having BA (35 having allergic and 16 - non-allergic form). The concentration of the buds in blood serum was defined using immunoenzyme method.
Results: Bitter taste buds' TAS2R31 concentration in blood serum of the practically healthy people didn't have statistically significant difference from the same in patients having BA. However in case of non-allergic course of disease the level of TAS2R31 was 1.7 times higher than in the event of allergic one. Both BA variations were characterized by inverse correlation of the concentration TAS2R31 and external breath functioning indicators reflecting patency of bronchi of the average and little caliber. In case of allergic BA statistical significance was demonstrated by direct correlation between serum concentrations of the TAS2R31 and general immunoglobulin E, cortisol, factor of tumor-a necrosis. Direct correlation between the level of buds with the increased emphasis on basophilia of the peripheral blood, and also content of macrophages, neutrophils and bronchial epithelium in mucus was found. In case of non-allergic BA such clinical phenomena as medicinal and fungi sensitization, myocardial infarction in anamnesis, conducting glucocorticoid therapy defined statistically significant correlation with the level of buds in blood serum.
Conclusions: Findings provide additional facts to prove hypothesis about negative regulation of the membrane buds TAS2R by plasma soluble taste buds. Further issue development should be directed to matching expression of the membrane and free plasma taste buds TAS2R.
About the Authors
V. N. Mineev
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Valeriy N. Mineev, MD, PhD, professor, Hospital Therapy Department.
6–8 Lva Tolstogo St., Saint Petersburg, 197022
M. A. Nyoma
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Mikhail A. Nyoma, MD, PhD, docent, Hospital Therapy Department.
6–8 Lva Tolstogo St., Saint Petersburg, 197022
V. I. Trofimov
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Vasiliy I. Trofimov, MD, PhD, professor, head of the Hospital Therapy Department.
6–8 Lva Tolstogo St., Saint Petersburg, 197022
References
1. Mineev VN, Trofimov VI, Nyoma MA, Kuzikova AA. Bitter taste receptors in serum of patients with asthma (a hypothesis). Pulmonologiya. 2017;27(5):567-72 (In Russ).
2. Mineev VN. Ectopic olfactory receptors in the respiratory system. Pulmonologiya. 2019;29(6):734-8 (In Russ).
3. Lee SJ, Depoortere I, Hatt H. Therapeutic potential of ectopic olfactory and taste receptors. Nat Rev Drug Discov. 2019;18(2):116-38.
4. Nayak AP, Villalba D, Deshpande DA. Bitter taste receptors: An answer to comprehensive asthma control? Curr Allergy Asthma Rep. 2019;19(10):48. doi: 10.1007/s11882-019-0876-0
5. Robinett KS, Koziol-White CJ, Akoluk A, An SS, Panettieri RA Jr, Liggett SB. Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells. Am J Respir Cell Mol Biol. 2014;50(4):678-83.
6. Liggett S.B. Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators. Expert Opin Ther Targets. 2013; 17(6):721-31.
7. Mineev VN. Koncepciya bronhial'noj astmy kak membrano-receptornoj patologii. Im-munopatologiya, Allergologiya, Infektologiya. 2005;3:68-85 (In Russ).
8. Fedoseev GB, Batagov SYa, Mineev VN, Nemtsov VI. Problemy prichinnosti vo vnutrennej patologii. Terapevticheskij arhiv. 1987;10:136-40 (In Russ).
9. Orsmark-Pietras C, James A, Konradsen JR, Nordlung B, So-derhall C, Pulkkinen V, et al. Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics. Eur Respir J. 2013;42:65-78.
10. Fedoseev GB. Chastnaya allergologiya. Vol 2. St. Petersburg: Nordmed-Izdat; 2001 (In Russ).
11. Bloxham CJ, Foster SR, Thomas WG. A bitter taste in your heart. Front Physiol. 2020;11:431. doi: 10.3389/fphys.2020.00431
12. Shiffman D, O’Meara ES, Bare LA, Shiffman D, ES, Bare LA, et al. Association of gene variants with incident myocardial infarction in the cardiovascular health study. Arterioscler Thromb Vasc Biol. 2008;28:173-9.
13. Grassin-Delyle S, Salvator H, Mantov N, Abrial C, Brollo M, Faisy C, et al. Bitter taste receptors (TAS2Rs) in human lung macrophages: Receptor expression and inhibitory effects of TAS2R agonists. Front Physiol. 2019;10:1267. doi: 10.3389/fphys.2019.01267
14. TAS2R31. Human Protein Atlas. URL: www.proteinatlas.org/ ENSG00000256436-TAS2R31
15. Mineev VN, Trofimov VI, Sorokina LN, Nyoma MA, Kuzikova AA. Blood serum bitter taste receptors and total IgE in allergic bronchial asthma in women. Immunopathology, Allergology, Infectology. 2017;3:35-40 (In Russ).
Review
For citations:
Mineev V.N., Nyoma M.A., Trofimov V.I. Ectopic taste buds TAS2R31 in blood serum in different types of bronchial asthma. Pacific Medical Journal. 2021;(1):68-71. (In Russ.) https://doi.org/10.34215/1609-1175-2021-1-68-71
Views:
261
Email this article 