Antioxidant properties of a combined medicine containing amberic acid with thermal influence on the organism
https://doi.org/10.34215/1609-1175-2021-1-76-79
Abstract
Objective: To estimate the efficiency of the influence of a combined medicine containing amberic acid on antioxidant status of the warm-blooded organism in the conditions of temperature effect.
Methods: Thermal model of the experiment conducted on 120 white outbred male rats weighting from 180 to 200 grams for the period of 21 days was used. Animals were divided into four groups: intact, control and two experimental. The last got intra-abdominal injections containing 50 or 100 mg/kg of amberic acid.
Results: Everyday thermal impact during 45 minutes fostered an increase in hydroperoxides of lipids (by 32 to 36 %), diene conjugates (by 36 to 38 %) and malonic dialdehyde (by 51 to 59 %) on the background of a decline in activity of the basic components of the antioxidant system. Injection of a combined medicine containing amberic acid contributes to a credible reduction of hydroperoxides of lipids (by 20 to 24 %), diene conjugates (by 20 to 21 %) and malonic dialdehyde (by 28 to 35 %) in blood plasma. Ceruloplasmin content in animal blood of the experimental groups was credibly higher than comparable figure of rats of the control group by 22-35 %, vitamin E - by 16-28 %, catalase - by 22-35 %.
Conclusions: The usage of a combined medicine containing amberic acid in condition of prolonged temperature effect on the organism of the experimental animals leads to stabilizing processes of peroxidation on the background of increase in the activity of the basic components of the antioxidant system.
About the Authors
O. N. Li
Pacific State Medical University
Russian Federation
Russian Federation
Olga N. Li, MD, PhD, professor, General and Clinical Pharmacology Department.
2 Ostryakova Ave., Vladivostok, 690002
A. V. Tyrtyshnikova
Pacific State Medical University
Russian Federation
Russian Federation
Anna V. Tyrtyshnikova, MD, PhD, associate professor, General and Clinical Pharmacology Depart-ment.
2 Ostryakova Ave., Vladivostok, 690002
A. V. Kropotov
Pacific State Medical University
Russian Federation
Russian Federation
Alexander V. Kropotov, MD, PhD, professor, Department of General and Clinical Pharmacology.
2 Ostryakova Ave., Vladivostok, 690002
T. N. Sedyh
Pacific State Medical University
Russian Federation
Russian Federation
Tamara N. Sedyh, MD, PhD, associate professor, Department of General and Clinical Pharmacology.
2 Ostryakova Ave., Vladivostok, 690002
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Review
For citations:
Li O.N., Tyrtyshnikova A.V., Kropotov A.V., Sedyh T.N. Antioxidant properties of a combined medicine containing amberic acid with thermal influence on the organism. Pacific Medical Journal. 2021;(1):76-79. (In Russ.) https://doi.org/10.34215/1609-1175-2021-1-76-79
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