Monitoring of preventive treatment of children having latent tuberculosis infection
https://doi.org/10.34215/1609-1175-2021-2-43-46
Abstract
Objective: To estimate the effectiveness of preventive treatment for children having latent tuberculosis infection according to the dynamics of the recombinant tuberculosis allergen (RTA) test.
Methods: The retrospective analysis of the life anamnesis, epidemic anamnesis and the results of the helical computed tomography of the thoracic organs was carried out among 388 children from 2 to 17 years old with positive RTA test results who got preventive treatment course. The dynamics of the RTA test results were studied after one and two years of treatment.
Results: Screening using immunodiagnostics and the following helical computed tomography for children having positive results of the skin test allows to reveal latent tuberculosis infection and minimal post-tuberculous changes. Dense calcium up to 5 mm in lymph nodes and lungs were observed more often among children having hyperergic reaction on immunological test. After two years of preventive treatment among 30.9 % of children having normergic reaction on RTA the test conversion from positive to negative, and also the decrease of the average size of the of skin papules from 11.3 to 5.4 mm was observed. Among children having hyperergic results of the RTA test a decrease of the average size of the papules from 15.6 to 7.2 mm was observed after chemotherapy. Among this group the decrease in the number of hyperergic tests (down to 8.6 %) was registered two years after observation.
Conclusions: Annual monitoring of the RTA tests results can be used to estimate the effectiveness of preventive treatment of the latent tuberculosis infection among children and adolescents.
About the Authors
O. D. Baronova
Regional Clinical Tuberculosis Dispensary
Russian Federation
Russian Federation
MD, PhD
56 Dostoevskogo St., Stavropol, 355019, Russian Federation
N. N. Moiseeva
Regional Clinical Tuberculosis Dispensary
Russian Federation
Russian Federation
MD
56 Dostoevskogo St., Stavropol, 355019, Russian Federation
V. S. Odinets
Regional Clinical Tuberculosis Dispensary
Russian Federation
Russian Federation
MD, PhD, chief physician
56 Dostoevskogo St., Stavropol, 355019, Russian Federation
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Review
For citations:
Baronova O.D., Moiseeva N.N., Odinets V.S. Monitoring of preventive treatment of children having latent tuberculosis infection. Pacific Medical Journal. 2021;(2):43-46. (In Russ.) https://doi.org/10.34215/1609-1175-2021-2-43-46
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