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Clinical features of the gastrointestinal tract lesion in patients with a new coronavirus infection (COVID-19)

https://doi.org/10.34215/1609-1175-2021-2-99-100

Abstract

 900 patients hospitalized with the laboratory-confirmed new coronavirus infection were examined within Vladivostok Clinical Hospital # 1 from April 2020  to February 2021. 225 patients (62–65 years old) brought the complaint for diarrhea. In 10 % of cases diarrhea turned out to be the only symptom of the disease onset. Patients having new Coronavirus infection who were operated suffered diarrhea on the basis of antibacterial therapy in 2.5 % of observations. During postcovid period this symptom on the basis of multimorbidity was registered among 14 patients. In 2 cases the infection caused by Clostridium difficile was confirmed. 

About the Authors

L. V. Sakhonenko
Vladivostok Clinical Hospital No. 1
Russian Federation

 MD

22 Sadovaya St., Vladivostok, 690078, Russian Federation 



M. V. Mokshina
Pacific State Medical University
Russian Federation

MD, PhD, associate professor, Institute of Therapy

2 Ostryakova Ave., Vladivostok, 690002, Russian Federation



References

1. Ivashkin VT, Sheptulin AA, Zolnikova OYu, Okhlobystin AV, Poluektova EA, Trukhmanov AS. New coronavirus infection (COVID-19) and digestive system. Russian Journal Gastroenterology, Hepatology, Coloproctology. 2020;30(3):7–13 (In Russ).

2. Zolnikova ОYu, Dzhakhaya NL, Potskherashvili ND, Puzakov KB, Кiseleva OYu, Kokina NI, et al. Clinical traits of SARS-CoV-2 infection. Russian Journal Gastroenterology, Hepatology, and Coloproctology. 2020;30(6):28–39 (In Russ).

3. Yang X, Zhao J, Yan Q, Zhang Sh, Wang Y, Li Y. A case of COVID-19 patient with the diarrhea as initial symptom and literature review. Clin Res Hepatol Gastroenterol. 2020;S2210-7401(20)30085-1. doi: 10.1016/j.clinre.2020.03.013

4. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrier T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–80.e8.

5. Lin L, Jiang X, Zhang Z, Huang S, Zhang Z, Fang Z, et al. Gastrointestinal symptoms of 95 cases with SARS-CoV- 2 infection. Gut. 2020;69(6):997–1001.

6. Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for gastrointestinal infection of SARS-CoV-2. J Gastroenterol. 2020;158(6):P1831–3.E3. doi: 10.1053/j.gastro.2020.02.055

7. Xu XW, Wu XX, Jiang XG, Xu KJ, Ying LJ, Ma CL. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series. BMJ. 2020;368:m606. doi: 10.1136/bmj.m606

8. Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM. Epidemiological, clinical and virological characteristics of 74 cases of coronavirusinfected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020. doi: 10.1136/gutjnl-2020-320926

9. Sandhu A, Tillotson G, Polistico J, Salimnia H, Cranis M, Moshos L. Clostridioides difficile in COVID-19 patients, Detroit, Michigan, USA, March April 2020. Emerg Infect Dis. 2020;26(9):2272–4.

10. Han C, Duan С, Zhang S, Speigel B, Shi H, Wang W, et al. Digestive symptoms in COVID-19 patients with mild disease severity: Clinical presentation, stool viral RNA testing, and outcomes. Am J Gastroenterol. doi: 10.14309/ajg.0000000000000664

11. Zhang H, Kang Z, Gong H. The digestive system is a potential route of 2019-ncov infection: A bioinformatics analysisbased on single=cell transcriptomes. J bioRxiv. 2020. doi: 10.1101/2020.01.30.927806

12. Zheng T, Yang C, Wang HY, Chen X, Yu L, Wu CL, Sun H. Clinical characteristics and outcomes of COVID-19 patients with gastrointestinal symptoms admitted to Jianghan Fangcang Shelter Hospital in Wuhan, China. J Med Virol. 2020;10.1002/jmv.26146. doi: 10.1002/jmv.26146

13. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet. 2020;395(10223):P507–13. doi: 10.1016/S0140-6736(20)30211-7


Review

For citations:


Sakhonenko L.V., Mokshina M.V. Clinical features of the gastrointestinal tract lesion in patients with a new coronavirus infection (COVID-19). Pacific Medical Journal. 2021;(2):99-100. (In Russ.) https://doi.org/10.34215/1609-1175-2021-2-99-100

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ISSN 1609-1175 (Print)