Protein linking fatty acids and its genetic regulation in children having food allergy
https://doi.org/10.34215/1609-1175-2021-4-46-49
Abstract
Objective: Study the effect of the Ala54Thr FABP gene polymorphism on the produce of the intestinal FABP fraction in blood serum. urine and coprofiltrate in children having food allergies.
Methods: The content of the FABP intestinal fraction in urine, feces, and blood serum was determined using ELISA method. The study of FABP genes polymorphism (G163A, Ala54Thr) was carried out using PCR method.
Results: Statistically significant increase of the FABP level in blood serum, urine and feces in children with FA was detected in various biological fluids. The distribution of FABP2 alleles and genotypes obeyed the Hardy-Weinberg law (χ 2 = 0; p = 1,000) and did not significantly differ from the distribution of genotypes in children having FA andin the control sample (p = 0.638).
Conclusions: The study did not reveal an association of the pathological genotype FABP G163A, (Ala54Thr) with the hyperproduction of the FABP intestinal fraction in children having FA, confirming the diagnostic significance of this marker increase during exacerbation of the disease.
About the Authors
N. G. Prikhodchenko
Pacific State Medical University
Russian Federation
Russian Federation
Prikhodchenko Nelli, Associate Professor, Doctor of Medical Sciences, Professor of the Institute of Pediatrics
690002, Vladivostok, Ostryakova Avenue 2
T. A. Shumatova
Pacific State Medical University
Russian Federation
Russian Federation
Shumatova Tatyana, Doctor of Medical Sciences, Professor, Director of the Institute of Pediatrics
690002, Vladivostok, Ostryakova Avenue 2
S. V. Voronin
Regional Clinical Center for Specialized Types of Medical Care, Regional medical genetic consultation
Russian Federation
Russian Federation
Voronin Sergey, Head of the KMGK Department
Vladivostok
D. V. Kovalenko
Pacific State Medical University
Russian Federation
Russian Federation
Kovalenko Daria Vadimovna, assistant of the Institute of Pediatrics
690002, Vladivostok, Ostryakova Avenue 2
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Review
For citations:
Prikhodchenko N.G., Shumatova T.A., Voronin S.V., Kovalenko D.V. Protein linking fatty acids and its genetic regulation in children having food allergy. Pacific Medical Journal. 2021;(4):46-49. (In Russ.) https://doi.org/10.34215/1609-1175-2021-4-46-49
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