ROLE OF STREPTOCOCCUS PNEUMONIAE IN THE ETIOLOGY OF COMMUNITY-ACQUIRED PNEUMONIA IN A LARGE INDUSTRIAL REGION OF THE RUSSIAN FEDERATION

Abstract

Objective. Study objective is to analyze the features of epidemiological process of community-acquired pneumonia and the role of separate serotypes of Streptococcus pneumoniae in the etiology. Methods. We used the data of state statistical reports for 20062016. To assess the role of S. pneumoniae in the etiology of community-acquired pneumonia we conducted epidemiological study using molecular and genetic methods of diagnostics of pneumonia in two cities of the region with participation of 957 patients. Results. It was determined that Sverdlovsk region is a contamination zone of community-acquired pneumonia with long-term annual average of incidence rate of 517.6 per 100 000 population. The highest level of incidence rate was registered among children under 6 y.o. and adults over 60 y.o. It was separated 167 DNA of S. pneumoniae. The most significant serotypes from 15 serogroups in developing of community-acquired pneumonia were 14, 6 A/B/C/D, 15 A/F and 19F. Conclusions. To control the epidemic situation for community-acquired pneumonia, continuous monitoring of the circulating serotypes of the pathogen and optimization of the composition of the pneumococcal serotypes entering the vaccine against pneumococcal infection are necessary. The tactics of vaccinating children against pneumococcal infection requires further improvement, in terms of immunizing not only the children of the first year of life in the National calendar of preventive vaccinations, but also the "catch-up" immunization of all the unvaccinated until the age of 17.