Comparative characterization of interleukin genotypes and risks of bronchial asthma phenotypes in children
V. B. Shumatov, 
E. V. Prosekova,
M. S. Dolgopolov,
A. I. Turyanskaya,
V. K. Kovalchuk,
V. A. Sabynych
E. V. Prosekova,
M. S. Dolgopolov,
A. I. Turyanskaya,
V. K. Kovalchuk,
V. A. Sabynych https://doi.org/10.34215/1609-1175-2024-1-5-10
Abstract
The present paper analyses genetic predictors of various endotypes and phenotypes of bronchial asthma in children. The review of data on the structure and prevalence of single-nucleotide polymorphisms of interleukin genes demonstrates their correlation with the risk of virus-induced and allergen-induced phenotypes of bronchial asthma. Significant differences in genotypes correlate with aberrant production of interleukin and the risks for developing various phenotypes of the disease. The studies into genetic factors indicate the significance of functional polymorphisms of interleukin genes as predictors associated with phenotypes and risk of the disease.
About the Authors
V. B. Shumatov
Pacific State Medical University
Russian Federation
Russian Federation
Vladivostok
E. V. Prosekova
Pacific State Medical University
Russian Federation
Russian Federation
Elena V. Prosekova, Dr. Sci. (Med.), Full Professor, Head of Department of Clinical Laboratory Diagnostics and General and Clinical Immunology
2 Ostryakova Ave, Vladivostok, 690002
M. S. Dolgopolov
Pacific State Medical University
Russian Federation
Russian Federation
Vladivostok
A. I. Turyanskaya
Pacific State Medical University
Russian Federation
Russian Federation
Vladivostok
V. K. Kovalchuk
Pacific State Medical University
Russian Federation
Russian Federation
Vladivostok
V. A. Sabynych
Pacific State Medical University
Russian Federation
Russian Federation
Vladivostok
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Review
For citations:
Shumatov V.B., Prosekova E.V., Dolgopolov M.S., Turyanskaya A.I., Kovalchuk V.K., Sabynych V.A. Comparative characterization of interleukin genotypes and risks of bronchial asthma phenotypes in children. Pacific Medical Journal. 2024;(1):5-10. (In Russ.) https://doi.org/10.34215/1609-1175-2024-1-5-10
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