Morphogenetic and growth factors in damaging to the dentin-pulp complex and periodontium
https://doi.org/10.34215/1609-1175-2024-1-11-16
Abstract
Morphogenetic and growth molecules, a key participant in reparative dentinogenesis, determine viability of the dentin-pulp complex (DPC), periodontium and dentogingival junction. They are secreted in microvessels, nerve fibers and connective tissue cells of the dental pulp, exerting homeostatic influence on the immediate surrounding. The present paper reviews the data on the localization of growth factors and signaling mechanisms that control histogenesis and reparative processes in the DPC. The paper points out the significance of these factors in the regulation of proinflammatory and immunocompetent cells in caries, periodontitis and osteoinductive processes in the alveolar outgrowth. The study of growth molecules appears crucial in the development of the latest clinical strategies to maintain the viability of the DPC and to integrate artificial materials in dental tissue restoration.
About the Authors
S. S. Edranov
Pacific State Medical University
Russian Federation
Russian Federation
Vladivostok
S. G. Kalinichenko
Pacific State Medical University
Russian Federation
Russian Federation
Vladivostok
N. Yu. Matveeva
Pacific State Medical University
Russian Federation
Russian Federation
Natalya Yu. Matveeva, Dr. Sci. (Med.), Head of the Department of Histology, Embryology and Cytology
2 Ostryakova Ave, Vladivostok, 690002
I. V. Kovaleva
Pacific State Medical University
Russian Federation
Russian Federation
Vladivostok
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Review
For citations:
Edranov S.S., Kalinichenko S.G., Matveeva N.Yu., Kovaleva I.V. Morphogenetic and growth factors in damaging to the dentin-pulp complex and periodontium. Pacific Medical Journal. 2024;(1):11-16. (In Russ.) https://doi.org/10.34215/1609-1175-2024-1-11-16
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