Biofilms on medical devices: Formation mechanisms and prevention techniques
https://doi.org/10.34215/1609-1175-2025-1-10-15
Abstract
This paper analyzes the mechanisms of biofilm formation on the surfaces of medical devices. On the basis of various experimental studies, prevention techniques for biofilm formation implying various substances that reduce the adhesion of microorganisms to the surface of the device and perform antibacterial activity are described.
About the Authors
V. N. YemelyanovRussian Federation
V. A. Virko
Russian Federation
Viktor A. Virko, Junior Researcher,
Akademika Lebedeva str., St. Petersburg, 1940446
A. A. Ognedyuk
Russian Federation
References
1. Rakhmatullina MR, Nechaeva IA. Biofilms of microorganisms and their role in the formation of resistance to antibacterial drugs. Bulletin of Dermatology and Venereology. 2015; 2:58–62 (In Russ.).
2. Tsilikina EG, Minaeva NZ, Gaponov MA, Tutelyan AV. Biofilms as a form of existence of infectious agents associated with medical care. Epidemiological aspects of the problem. Epidemiology and Infectious Diseases. Current Items. 2015; 6: 54–61(In Russ.).
3. Malafeeva EV, Gulneva EV, Noskov MYu, Romanov VA. The formation of bio-films by opportunistic microorganisms isolated from patients with rheumatic disease. Clinical Laboratory Diagnostics. 2014; 11 (In Russ.).
4. Jamal M, Ahmad W, Andleeb S, Jalil F, Imran M, Nawaz MA, Hussain T, Ali M. Bacterial biofilm and associated infections. Journal of the chinese medical association. 2018; 81(1):7–11. doi: 10.1016/j.jcma.2017.07.012
5. Song F, Koo H, Ren D. Effects of material properties on bacterial adhesion and biofilm formation. Journal of dental research. 2015; 94 (8): 1027–1034. doi: 10.1177/002203451558769
6. Pal Z, Urban E, Dosa E, Pál A, Nagy E. Biofilm formation on intrauterine devices in relation to duration of use. Journal of medical microbiology. 2005; 54 (12): 1199–1203. doi: 10.1099/jmm.0.46197-0
7. Khelissa SO, Jama C, Abdallah M, Boukherroub R. Effect of incubation duration, growth temperature, and abiotic surface type on cell surface properties, adhesion and pathogenicity of biofilm-detached Staphylococcus aureus cells. AMB Express. 2017; 7: 1–13. doi: 10.1186/s13568-017-0492-0
8. Bjarnsholt T. The role of bacterial biofilms in chronic infections. Apmis. 2013; (121): 1–58. doi: 10.1111/apm.12099
9. Rumbaugh KP, Trivedi U, Watters C, Burton-Chellew MN, Diggle SP, West SA. Kin selection, quorum sensing and virulence in pathogenic bacteria. Proceedings of the Royal Society B: Biological Sciences. 2012; 279 (1742): 3584–3588. doi: 10.1098/rspb.2012.0843
10. Ramasamy M, Lee J. Recent Nanotechnology Approaches for Prevention and Treatment of Biofilm-Associated Infections on Medical Devices. Biomed Res Int. 2016. doi: 10.1155/2016/1851242
11. Di Domenico EG, Oliva A, Guembe M. The Current Knowledge on the Pathogenesis of Tissue and Medical Device-Related Biofilm Infections. Microorganisms. 2022; 10(7) : 1259. doi: 10.3390/microorganisms10071259
12. Vandecandelaere I, Coenye T. Microbial composition and antibiotic resistance of biofilms recovered from endotracheal tubes of mechanically ventilated patients. Adv Exp Med Biol. 2015; 830: 137–155. doi: 10.1007/978-3-319-11038-7_9
13. Solomai TV. Prevention of diseases associated with biofilms formed on abiotic surfaces in medical organizations. Sanitarnyj Vrach. 2017; 7: 37–45. (In Russ.).
14. Higgins M, Zhang L, Ford R, Brownlie J, Kleidon T, Rickard CM, Ullman A. The microbial biofilm composition on peripherally inserted central catheters: A comparison of polyurethane and hydrophobic catheters collected from paediatric patients. J. Vasc. Access. 2021; 22 (3): 388–393. doi: 10.1177/11297298209324
15. Percival SL, Suleman L, Vuotto C, Donelli G. Healthcareassociated infections, medical devices and biofilms: risk, tolerance and control. J Med Microbiol. 2015; 64 (4): 323–334. doi: 10.1099/jmm.0.000032
16. Besarab A, Pandey R. Catheter management in hemodialysis patients: delivering adequate flow. Clinical Journal of the American Society of Nephrology. 2011; 6 (1): 227–234. doi: 10.2215/CJN.04840610
17. Balne PK, Harini S, Dhand C, Dwivedi N, Chalasani MS, Verma NK. Surface characteristics and antimicrobial properties of modified catheter surfaces by polypyrogallol and metal ions. Materials Science and Engineering. 2018; 90: 673–684. doi: 10.1016/j.msec.2018.04.095
18. Zampieri FG, De Oliveira NE, Nassar Jr AP, de Oliveira Manoel AL, Grion C Lacerda. Bundle of Coated Devices to Reduce Nosocomial Infections in the Intensive Care Unit. CRITIC Pilot Randomized Controlled Trial. Ann Am Thorac Soc. 2020; 17 (10): 1257–1263. doi: 10.1513/AnnalsATS.202003-206OC
19. Batista OA, Monteiro RM, Machado MB, Domingues PC, Watanabe E, Andrade D. Biofilms formation and prevention on urinary catheters: A bibliometric analysis. Bioscience Journal. 2020; 1058–1065.
20. Pinegina ON, Vasilyeva NV, Saturnov AV. Species composition of microorganisms, biofilm formation and colonization of central venous and urethral catheters. Problems in Medical Mycology. 2013; 4: 81–85 (In Russ.) т ь.
21. Gauhar V, Castellani D, Teoh JY, Nedbal C, Chiacchio G, Gabrielson AT, Heldwein FL, Wroclawski ML, de la Rosette J, Donalisio da Silva R, Galosi AB, Somani BK. Catheter-Associated Urinary Infections and Consequences of Using Coated versus Non-Coated Urethral Catheters-Outcomes of a Systematic Review and Meta-Analysis of Randomized Trials. J. Clin. Med. 2022; 11 (15): 44–63. doi: 10.3390/jcm11154463
22. Tae BS, Oh JJ, Jeong BC, Ku JH. Catheter-associated urinary tract infections in patients who have undergone radical cystectomy for bladder cancer: A prospective randomized clinical study of two silicone catheters (clinical benefit of antibiotic silicone material). Investig Clin Urol. 2023; 63 (3): 334–340. doi: 10.4111/icu.20210436
23. Mahmoodpoor A, Sanaie S, Parthvi R, Shadvar K, Hamishekar H, Iranpour A, Nuri H, Rahnemayan S, Nader ND. A clinical trial of silver-coated and tapered cuff plus supraglottic suctioning endotracheal tubes in preventing ventilator-associated pneumonia. J Crit Care. 2020; 56: 171–176. doi: 10.1016/j.jcrc.2019.12.024
24. Tincu RC, Cristian C, Tincu FJ, Radu AM. Efficacy of Noble Metal-alloy Endotracheal Tubes in Ventilator-associated Pneumonia Prevention: a Randomized Clinical Trial. Balkan Med J. 2023; 39(3): 167–171. doi: 10.4274/balkanmedj.galenos.2021.2021-7-86
25. Rodríguez-Merchán EC, Davidson DJ, Liddle AD. Recent Strategies to Combat Infections from Biofilm-Forming Bacteria on Orthopaedic Implants. Int. J. Mol. Sci. 2021; 22. doi: 10.3390/ijms221910243
26. Francolini I, Piozzi A, Donelli G. Efficacy evaluation of antimicrobial drug-releasing polymer matrices. Methods Mol Biol. 2014; 1147: 215–225. doi: 10.1007/978-1-4939-0467-9_15
27. Antony S, Farran Y. Prosthetic Joint and Orthopedic Device Related Infections. The Role of Biofilm in the Pathogenesis and Treatment. Infect Disord Drug Targets. 2016; 16 (1): 22–27.
28. Malizos K, Blauth M, Danita A, Capuano N, Mezzoprete R, Logoluso N, Drago L. Fast-resorbable antibiotic-loaded hydrogel coating to reduce post-surgical infection after internal osteosynthesis: a multicenter randomized controlled trial. J Orthop Traumatol. 2017; 18 (2): 159–169. doi: 10.1007/s10195-017-0442-2
29. Hu H, Jacombs A, Vickery K, Merten SL. Chronic Biofilm Infection in Breast Implants Is Associated with an Increased T-Cell Lymphocytic Infiltrate: Implications for Breast Implant-Associated Lymphoma. Plastic and Reconstructive Surgery. 2015; 135 (2): 319–329. doi: 10.1097/PRS.0000000000000886
30. Rieger UM, Mesina J, Kalbermatten DF, Haug M, Frey HP, Pico R, Frei R, Pierer G, Lüscher NJ, Trampuz A. Bacterial biofilms and capsular contracture in patients with breast implants. Br. J. Surg. 2013; 100 (6): 768–774. doi: 10.1002/bjs.9084
31. James GA, Boegli L, Hancock J, Bowersock L, Parker A, Kinney BM. Bacterial Adhesion and Biofilm Formation on Textured Breast Implant Shell Materials. Aesthetic Plastic Surgery. 2019; 43: 490–497. doi: 10.1007/s00266-018-1234-7
32. Sousa AF, Marques DM, Monteiro RM, Queiroz AA, Andrade D, Watanabe E. Prevention of biofilm formation on artificial pacemakers: is it feasible? Acta Paul Enferm. 2017; 30(6): 644–650. doi: 10.1590/1982-0194201700085
33. Dilmukhametova DN, Musin IN. Biofilms: main research methods and methods of combating them. Vestnik Nauki. 2024; 2 (6): 1937–1943 (In Russ.).
Review
For citations:
Yemelyanov V.N., Virko V.A., Ognedyuk A.A. Biofilms on medical devices: Formation mechanisms and prevention techniques. Pacific Medical Journal. 2025;(1):10-15. (In Russ.) https://doi.org/10.34215/1609-1175-2025-1-10-15