THE ROLE OF DERANGEMENTS IN HYALINE CARTILAGE REMODELING IN PATHOGENESIS OF THE EARLY STAGES OF KNEE OSTEOARTHROSIS

Abstract

Objective: The objective is to study the role of hyaline cartilage remodeling disorders in the early stages of osteoarthrosis. Methods: We examined 73 female patients with early knee osteoarthrosis symptoms and 20 healthy women (average age 52 y.o). All patients were examined with magnetic resonance imaging, sonography for knee joints; blood serum levels were determined for interleukin-1ß, neopterin, highly sensitive C-reactive protein, osteocalcin, CrossLaps, pyridinoline, oligomeric cartilage matrix protein (Human Cartilage Oligomaric Matrix Protein - COMP) and cartilage glycoprotein YKL-40. Results: We noted an increase of interleukin-1ß level at normal values of C-reactive protein and neopretin in blood serum. Markers of remodeling of cartilage and bone tissue (osteocalcin, Cross-Laps, pyridinoline, COMP and cartilage glycoprotein YKL-40) showed a significant increase of concentration compared with control values. Conclusions: Cytokine imbalance with pronounced hyperproduction of interleukin-1ß plays a leading role in the pathogenesis of the early stages of primary osteoarthritis of the knee joints. Degenerative and dystrophic and inflammatory processes affecting the subchondral bone, synovium, hyaline cartilage, medial menisci, and also separate components of capsular ligamentous apparatus these joints develop against the remodeling disorders of bone and cartilage tissues.