PHARMACOECONOMIC EVALUATION OF BIOSIMILAR RECOMBINANT ALPHA-EPOETIN IN THE TREATMENT OF ANEMIA IN HEMODIALYSIS PATIENTS WITH CHRONIC KIDNEY DISEASE
https://doi.org/10.17238/PmJ1609-1175.2019.1.50-56
Abstract
Objective: The objective is to conduct a clinical and economic analysis of effectiveness of recombinant human erythropoietin (rhEPO), used to treat anemia in adult patients with dialysis-dependent terminal chronic kidney disease. Methods: The study takes into account the direct medical costs of therapy with rhEpO: epoetin-alpha (Eralfon), darbepoetin-alpha (Aranesp) and epoetin-beta (methoxypolyethylene glycol, Mircera) for both intravenous and subcutaneous administration. A "cost minimization" analysis has been performed for equivalent doses of erythropoietin. Results: With equal effectiveness of the studied drugs "Eralfon" 2500 IU intravenous turned out to be less expensive medicinal technology in relation to equivalent doses of "Aranesp" 20 μg and "Mircera" 75 цд and 75+50 цд - by 29 and 26 and 4 %, respectively. The transfer of patients to subcutaneous administration can reduce the weekly dose of epoetin-alpha by 20-30 % by reducing the frequency of taking the drug to twice a week, which reduces the cost of drug therapy. A subcutaneous administration of «Eralfon» 2500 IU is a cost-effective drug technology: savings can range from 58,380 to 117,156 rubles per patient per year. Conclusions: Intravenous and subcutaneous administration of Eralfon 2500 IU can be considered more economical drug technology relative to Aranesp and Myrcera.
About the Authors
I. S. Krysanov
Medical Institute of Continuing Education, Moscow State University of Food Production; Institute of Clinico-Economic Expertise and Pharmacoeconomics
Russian Federation
Russian Federation
V. Yu. Ermakova
Institute of Clinico-Economic Expertise and Pharmacoeconomics
Russian Federation
Russian Federation
L. B. Vaskova
Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
M. V. Tiapkina
Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
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For citations:
Krysanov I.S., Ermakova V.Yu., Vaskova L.B., Tiapkina M.V. PHARMACOECONOMIC EVALUATION OF BIOSIMILAR RECOMBINANT ALPHA-EPOETIN IN THE TREATMENT OF ANEMIA IN HEMODIALYSIS PATIENTS WITH CHRONIC KIDNEY DISEASE. Pacific Medical Journal. 2019;(1):50-56. (In Russ.) https://doi.org/10.17238/PmJ1609-1175.2019.1.50-56
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