THE STUDY OF MEMBRANE-PROTECTIVEAND AND ANTIOXIDANT POTENTIALS OF CITICOLINE AND ETHYLMETHYLHYDROXYPYRIDINE WITH COMBINED USAGE

Objective: We studied an antioxidant status and phospholipid blood plasma composition of patients with chronic brain ischemia during individual use of 2-ethyl-6-methyl-3-hydroxypyri-dine succinate ('Neurox'), citicoline ('Neipelept'). Methods: The study included 40 patients aged 54-72 y.o. with chronic brain ischemia 2 stage in the decompensating phase. The 1st group (14 patients) took 'Neurox' in addition to a basic regimen, the 2nd group (13 patients) - 'Neipelept', the 3d group (13 patients) - a combination of these drugs. The control group -14 healthy people aged 24-42 y.o. Results: Having used a combination therapy with the drugs 'Neurox' and 'Neipelept', a significant increase of superoxide dismutase activity in blood plasma after the end of treatment was registered. A significant increase of reduced SH-groups number was detected after the treatment with 'Neurox. Having studied quantitative and qualitative composition of blood phospholipids in patients taking 'Neurox', significant changes in their mass was not detected; meanwhile having used'Neipelept' and the combinations of these drugs, there was an increase of content and total mass of phospholipids. Conclusions: Clinical data and results of biochemical analysis signify the applicability of ethylmethylhydroxypyridine succinate and citicoline, and also their combinations as part of neuroprotective therapy of chronic brain ischemia.

brain ischemia, neipelept, neurox, phospholipids

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