Vascular dysfunction and periadventitial adipose tissue
Abstract
Over the last years, concerted efforts have helped to uncover and understand the basic mechanisms of periadventitial regulation of arterial tone by perivascular adipose tissue. Basically, perivascular adipose tissue serves as source for “Adipocyte-derived relaxing factor” (ADRF), an essential player in the control of vascular tone of visceral and other arteries. Importantly, its disturbed local, paracrine activity is able to cause vascular dysfunction. Hydrogen sulfide (H2S) is a putative candidate for ADRF, which has received increased attention. The importance of this and other candidates for periadventitial vasoregulation has been recently explored in rodent models of obesity, hypertension and metabolic syndrome. Pharmacological tools have been successfully used to clarify the role of potassium channels involved in these conditions. Vasoactive factors of adipocytes or their receptors could represent targets for the development of novel cardiovascular drugs.
About the Authors
D. .. Tsvetkov
Charite University Medicine Berlin
Russian Federation
Russian Federation
I. A. Szijârto
Charite University Medicine Berlin
Russian Federation
Russian Federation
N. .. Wang
Charite University Medicine Berlin
Russian Federation
Russian Federation
J. -Y. Tano
Charite University Medicine Berlin
Russian Federation
Russian Federation
M. .. Gollasch
Charite University Medicine Berlin
Russian Federation
Russian Federation
References
1. Adams K.F., Schatzkin A., Harris T.B. [et al.]. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old // N. Engl. J. Med. 2006. Vol. 355. P. 763-778.
2. Agabiti-Rosei C., De Ciuceis C., Rossini C. [et al.]. Anticontractile activity of perivascular fat in obese mice and the effect of long-term treatment with melatonin // J. Hypert. 2014. Vol. 32. P. 1264-1274.
3. Engeli S. Is there a pathophysiological role for perivascular adipocytes? // Am. J. Physiol. Heart Circ. Physiol. 2005. Vol. 289. P. H1794-1795.
4. Fesus G., Dubrovska G., Gorzelniak K. [et al.]. Adiponectin is a novel humoral vasodilator // Cardiovasc. Res. 2007. Vol. 75. P. 719-727.
5. Galic S., Oakhill J.S., Steinberg G.R. Adipose tissue as an endocrine organ // Mol. Cell Endocrinol. 2010. Vol. 316. P. 129-139.
6. Galvez B., de Castro J., Herold D. [et al.]. Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats // Arteriosclerosis, Thrombosis, and Vascular Biology. 2006. Vol. 26. P. 1297-1302.
7. Galvez-Prieto B., Dubrovska G., Cano M.V [et al.]. A reduction in the amount and anti-contractile effect of periadventitial mesenteric adipose tissue precedes hypertension development in spontaneously hypertensive rats // Hypertension research. 2008. Vol. 31. P. 1415-1423.
8. Gao Y.J., Zeng Z.H., Teoh K. [et al.]. Perivascular adipose tissue modulates vascular function in the human internal thoracic artery // J. Thorac. Cardiovasc. Surg. 2005. Vol. 130. P. 1130-1136.
9. Gil-Ortega M., Somoza B., Huang Y. [et al.]. Regional differences in perivascular adipose tissue impacting vascular homeostasis // TEM. 2015. Vol. 26, No. 7. P. 367-375.
10. Gollasch M., Dubrovska G. Paracrine role for periadventitial adipose tissue in the regulation of arterial tone // Trends in Pharmacological Sciences. 2004. Vol. 25. P. 647-653.
11. Gollasch M. KCNQ channels and novel insights into coronary perfusion // Hypertension. 2013. Vol. 62. P. 1011-1012.
12. Gollasch M. Vasodilator signals from perivascular adipose tissue // Br. J. Pharmacol. 2012. Vol. 165. P. 633-642.
13. Greenstein A.S., Khavandi K., Withers S.B. [et al.]. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients // Circulation. 2009. Vol. 119. P. 1661-1670.
14. Kenchaiah S., Evans J.C., Levy D. [et al.]. Obesity and the risk of heart failure // N. Engl. J. Med. 2002. Vol. 347. P. 305-313.
15. Kohn C., Dubrovska G., Huang Y. Gollasch M. Hydrogen sulfide: potent regulator of vascular tone and stimulator of angiogenesis // Int. J. Biomed. Science. 2012. Vol. 8. P. 81-86.
16. Kohn C., Schleifenbaum J., Szijarto I.A. [et al.]. Differential effects of cystathionine-gamma-lyase-dependent vasodilatory H2S in periadventitial vasoregulation of rat and mouse aortas // PloS one. 2012. Vol. 7. P. e41951.
17. Lee R.M., Lu C., Su L.Y., Gao Y.J. Endothelium-dependent relax ation factor released by perivascular adipose tissue // J. Hypertens. 2009. Vol. 27. P. 782-790.
18. Lee Y.C., Chang H.H., Chiang C.L. [et al.]. Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis ofhypertension // Circulation. 2011. Vol. 124. P. 1160-1171.
19. Lohn M., Dubrovska G., Lauterbach B. [et al.]. Periadventitial fat releases a vascular relaxing factor // FASEB. 2002. Vol. 16. P. 1057-1063.
20. Lynch F.M., Withers S.B., Yao Z. [et al.]. Perivascular adipose tissue-derived adiponectin activates BK(Ca) channels to induce anticontractile responses // Am. J. Physiol. Heart Circulatory Physiol. 2013. Vol. 304. P. H786-795.
21. Malinowski M., Deja M.A., Janusiewicz P. [et al.]. Mechanisms of vasodilatatory effect of perivascular tissue of human internal thoracic artery // Journal of Physiology and Pharmacology. 2013. Vol. 64. P. 309-316.
22. Mensink G.B., Lampert T., Bergmann E. Overweight and obesity in Germany 1984-2003 // Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2005. Vol. 48. P. 1348-1356.
23. Schleifenbaum J., Kassmann M., Szijarto I.A. [et al.]. Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries // Circulation Research. 2014. Vol. 115. P. 263-272.
24. Schleifenbaum J., Kohn C., Voblova N. [et al.]. Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide // J. Hypertension. 2010. Vol. 28. P. 1875-1882.
25. Stewart S.T., Cutler D.M., Rosen A.B. Forecasting the effects of obesity and smoking on U.S. life expectancy // N. Engl. J. Med. 2009. Vol. 361. P. 2252-2260.
26. Tano J.Y., Schleifenbaum J., Gollasch M. Perivascular adipose tissue, potassium channels, and vascular dysfunction // Arteriosclerosis, Thrombosis, and Vascular Biology. 2014. Vol. 34. P. 1827-1830.
27. Verlohren S., Dubrovska G., Tsang S.Y. [et al.]. Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries // Hypertension. 2004. Vol. 44. P. 271-276.
28. Weston A.H., Egner I., Dong Y. [et al.]. Stimulated release of a hyperpolarizing factor (ADHF) from mesenteric artery perivascular adipose tissue: involvement of myocyte BKCa channels and adiponectin // Br. J. Pharmacol. 2013. Vol. 169. P. 1500-1509.
29. Wilson P.W., D'Agostino R.B., Sullivan L. [et al.]. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience // Arch. Intern. Med. 2002. Vol. 162. P. 1867-1872.
30. Zavaritskaya O., Zhuravleva N., Schleifenbaum J. [et al.]. Role of KCNQ channels in skeletal muscle arteries and periadventitial vascular dysfunction // Hypertension. 2013. Vol. 61. P. 151-159.
Review
For citations:
Tsvetkov D..., Szijârto I.A., Wang N..., Tano J.-., Gollasch M... Vascular dysfunction and periadventitial adipose tissue. Pacific Medical Journal. 2016;(2):31-33. (In Russ.)
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