Cancer stem cells of glioblastoma induce the migration of normal stem cells
https://doi.org/10.17238/1609-1175.2016.2.81
Abstract
The study had 3 stages: 1) the study of human SC migration processes to cells of malignant tumors in vitro; 2) comparison of cellular proteomes of some SC including tumor SC; 3) study of SC migration in vivo. It was used modern cellular and post-genomic technologies. Results. Neural SC had a higher mobility as compared to the multipotent mesenchymal SC and fibroblasts. We received the data on a sufficiently high affinity tumor glioblastoma SC and normal SC. Administration of mesenchymal SC labeled with fluorochrome to animals with glioma showed that the maximum number of these cells (57,6±8,9 %) was recorded in the brain. Conclusions. The transplantation of SC is the one of the main directions in the treatment of cancer due to high capacity of a cell transplant to find the damage zone. Among all the cells of glioblastoma, tumor SC have the best ability to attract normal SC. Critical differences of cellular proteomes allows considering the mesenchymal SC as the best tool for influencing tumor glioblastoma SC.
About the Authors
I. S. Bryukhovetskiy
Far Eastern Federal University, School of Biomedicine; A.V. Zhirmunsky Institute of Marine Biology of Far Eastern Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
I. V. Duyizen
Far Eastern Federal University, School of Biomedicine; A.V. Zhirmunsky Institute of Marine Biology of Far Eastern Branch of the Russian Academy of Sciences; Pacific States Medical University
Russian Federation
Russian Federation
V. E. Shevchenko
Far Eastern Federal University, School of Biomedicine; N.N. Blokhin Russian Cancer Research Center
Russian Federation
Russian Federation
Yu. S. Khotimchenko
Far Eastern Federal University, School of Biomedicine; A.V. Zhirmunsky Institute of Marine Biology of Far Eastern Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Bryukhovetskiy I.S., Duyizen I.V., Shevchenko V.E., Khotimchenko Yu.S. Cancer stem cells of glioblastoma induce the migration of normal stem cells. Pacific Medical Journal. 2016;(2):81-89. (In Russ.) https://doi.org/10.17238/1609-1175.2016.2.81
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