The morphological features of the rats brain at an acceleration in the neonatal dairy and periods of ontogenesis

Abstract

We studied the brain 5-, 14- and 30-day-old rats from the artificially reduced after a day birth of litters. Control rats were from intact litters. On the basis of morphometry we analyzed the brain mass and degree of development of its cortex, the state of neurons and the intensity of enzymatic reactions. Results. Animals of all age groups from small litters differed significantly by increased body weight, significantly greater than in the controls, and the mass of the brain hemispheres. Relative brain weight in rats of the experimental group was lower than in controls. Experimental animals had a range of morphological features to accelerate the maturation of the cerebral cortex. Conclusions. Experimental animals had an important sign of acceleration - a significant advance rate of body weight increase. Differences from control brain morphometric and histochemical parameters can be regarded as evidence of intensification of intramitochondrial and extramitochondrial biological oxidation. As they grow older early developed animals, a part of the differences of early life stages, reflecting both the level of brain ontogeny and functional state of neurons is negated.