Structural and functional recovery of the nervous tissue of the brain in the post-ischemic period from the standpoint of view of provisory in reparative histogenesis

Abstract

Education temporary (provisional) of the tissue in the process of reparative histogenesis is typical for bodies formed on the basis of full differones. The incomplete recovery of differones nervous tissue requires further study. Methods. We conducted an experimental study on sexually mature white rats (n=50), the embryos (n=5) and neonatal (n=5). After acute ischemia was studied structural and functional recovery of the nervous tissue of the cerebral cortex, cerebellum, hippocampus, ventrobasal thalamus and spinal cord. The actual material obtained during light microscopy (hematoxylin and eosin, Nissl) and electron microscopic study of brain dynamics in post-ischemic period. Results. Found that after ischemia, formed a special provisional substrate, “mobilized” to restore lost functions. It is characterized increased information capacity of the neural network - the excess plastic structural elements (immature, mature contacts, small spikes). Conclusions. The study made it possible to extend the principle of provisional on incomplete differones was found and examine the temporary substrate as a “tool” for ensuring the execution of essential functions in damaged by ischemia of the brain.