The role of mast cells in the pathogenesis of autoimmune thyroid diseases
https://doi.org/10.17238/PmJ1609-1175.2016.3.11-14
Abstract
This literature review describes the role of cells of innate immune system, mast cells, in the pathogenesis of autoimmune thyroid diseases. In recent years a large number of articles were about studying new immune properties of mast cells and, in particular, their effect on T-cells' functions through secretion of various cytokines. However, the articles that have been analyzed do not fully clarify an assumed ability of mast cells to directly activate T-cells through autoantigen presentation. Possible MHC class II expression by mast cells also remains disputable. This review considers a hypothesis that mast cells can control functional activity of immune cells and thyroid, provided they have appropriate effect. At present this assumption is considered to be a mechanism that triggers the pathogenesis of autoimmune thyroid diseases.
About the Authors
V. V. Zdor
Pacific State Medical University
Russian Federation
Russian Federation
B. I. Geltser
Pacific State Medical University
Russian Federation
Russian Federation
E. V. Markelova
Pacific State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Zdor V.V., Geltser B.I., Markelova E.V. The role of mast cells in the pathogenesis of autoimmune thyroid diseases. Pacific Medical Journal. 2016;61(3):11-14. (In Russ.) https://doi.org/10.17238/PmJ1609-1175.2016.3.11-14
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