Antibiotic treatment in patients with cataract surgery
https://doi.org/10.17238/PmJ1609-1175.2016.3.15-17
Abstract
Objective. Comparative analysis of bacterial population content of eye surface at local and systematical antibiotic treatment with fluoroquinolones in patients with cataract surgery. methods. The study included 185 patients (246 eyes) aged from 45 to 85 after cataract surgery. 92 patients got instillation of levofloxacin (0.5 %) 4 times per day during 3 days before the surgery, 93 patients got add-on fluoroquinolones systematically: orally, 500 mg/day. During the study it was conducted four stages of microbial examinations of conjunctival sac content: before the antibacterial treatment, in several hours before the surgery, after the surgery, and in 4-5 days after the surgery. results. Analysis of changes in the microbial contamination of the conjunctiva in the background of antibiotic prophylaxis, showed a negative value of the absolute increase (decrease) in both groups. Patients who received antibiotic prophylaxis the decrease rate was significantly higher (1.8 times). Conclusions. There is every reason to use the antibiotic scheme with the use of fluoroquinolones for systemic perioperative support cataract surgery in patients with a high risk of infectious complications.
About the Authors
E. V. Eliseeva
Pacific State Medical university
Russian Federation
Russian Federation
G. A. Fedyashev
Pacific State Medical university; Primorsky center of eye microsurgery fediashev@mail.ru
Russian Federation
Russian Federation
References
1. Калинин О.Б., Елисеева Е.В., Шевцов В.Д., Чанышев А.И. Профилактика инфекции области хирургического вмешательства при плановой лапароскопической холецистэктомии // Тихоокеанский медицинский журнал. 2009. № 4 (прил.). С. 60-61.
2. Общественное здоровье и здравоохранение, экономика здравоохранения: учебник [2 т.] / под ред. В.З. Кучеренко. М.: ГЕОТАР-Медиа, 2013.
3. Chung J.L., Lim E.H., Song S.W. [et al.]. Comparative intraocular penetration of 4 fluoroquinolones after topical instillation // Cornea. 2013. Vol. 32, No. 7. P. 1046-1051.
4. Gentile R.C., Shukla S., Shah M. [et al.]. Microbiological spectrum and antibiotic sensitivity in endophthalmitis: a 25-year review // Ophthalmology. 2014. Vol. 121, No. 8. P. 1634-1642.
5. George J.M., Fiscella R., Blair M. [et al.]. Aqueous and vitreous penetration of linezolid and levofloxacin after oral administration // J. Ocul. Pharmacol. Ther. 2010. Vol. 26, No. 6. P. 579-586.
6. Gower E.W., Keay L.J., Stare D.E. [et al.]. Characteristics of endophthalmitis after cataract surgery in the United States medicare population // Ophthalmology. 2015. Vol. 122, No. 8. P. 1625-1632.
7. Ishida M., Kataoka T., Niwa K. [et al.]. Efficient penetration into aqueous humor by administration of oral and topical levofloxacin // Ocul. Pharmacol. Ther. 2011. Vol. 27, No. 3. P. 247-250.
8. Kessner R., Golan S, Barak A. Changes in the etiology of endophthalmitis from 2003 to 2010 in a large tertiary medical center // Eur. J. Ophthalmol. 2014. Vol. 24, No. 6. P. 918-924.
9. Matsuura K., Mori T., Miyamoto T. [et al.]. Survey of Japanese ophthalmic surgeons regarding perioperative disinfection and antibiotic prophylaxis in cataract surgery // Clin. Ophthalmol. 2014. Vol. 29, No. 8. P. 2013-2018.
10. May W.N., Castro-Combs J., Kashiwabuchi R.T. [et al.]. Sutured clear corneal incision: wound apposition and permeability to bacterial-sized particles // Cornea. 2013. Vol. 32. P. 319-325.
11. Niyadurupola N., Astbury N. Endophthalmitis: controlling infection before and after cataract surgery // Community Eye Health. 2008. Vol. 21, No. 65. P. 9-10.
12. Sakamoto H., Sakamoto M., Hata Y. [et al.]. Aqueous and vitreous penetration of levofloxacin after topical and/or oral administration // Eur. J. Ophthalmol. 2007. Vol. 17, No. 3. P. 372-376.
13. Vaziri K., Schwartz S.G., Kishor K., Flynn, Y.W.Jr. Endophthalmitis: state of the art // Clin. Ophthalmol. 2015. Vol. 9. P. 95-108.
Review
For citations:
Eliseeva E.V., Fedyashev G.A. Antibiotic treatment in patients with cataract surgery. Pacific Medical Journal. 2016;61(3):15-17. (In Russ.) https://doi.org/10.17238/PmJ1609-1175.2016.3.15-17
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