Condition of aortic stiffness and content of adipokines in blood serum in patients of young and middle age with hypertension
Abstract
Background. Aortic stiffness has independent prognostic value in relation to the fatal and nonfatal car-diovascular events in patients with hypertension, particularly in patients of young and middle age. Methods. 50 observations of essential hypertension (EH) II stage in 23 men and 27 women 25-60 years evaluated the association between body mass index, cholesterol levels, adiponectin and blood leptin, pulse wave velocity, augmentation index and coronary perfusion area. Results. Obvious connection between plasma adiponectin concentration and the degree of aortic stiffness in patients with essential hypertension register failed. Adiponectin levels had a close negative cor-relation with body mass index, waist circumference and levels of cholesterol and triglycerides. Was founded direct link between tenuous relationship between coronary perfusion index and blood leptin. Also, the concentration of leptin was positively associated with weight and cholesterol levels. The greatest number of statistically significant relationships was observed in the group of women with EH. Conclusions. In hypertensive patients young and middle age regardless of gender increased aortic stiff-ness and violated the conditions of coronary perfusion. Interconnection of blood concentrations of leptin and adiponectin, and excessive stiffness of arterial bed, mostly expressed in women.
About the Authors
V. A. Nevzorova
Pacific State Medical University
Russian Federation
Russian Federation
T. A. Brodskaya
Pacific State Medical University
Russian Federation
Russian Federation
A. N. Sakovskaya
Pacific State Medical University
Russian Federation
Russian Federation
I. V. Chikalovets
G.B. Elyakova Pacific Institute of Bioorganic Chemistry Far Eastern Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Nevzorova V.A., Brodskaya T.A., Sakovskaya A.N., Chikalovets I.V. Condition of aortic stiffness and content of adipokines in blood serum in patients of young and middle age with hypertension. Pacific Medical Journal. 2015;(1):43-47. (In Russ.)
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