Bioelements in the correction of dismetabolic disorders among drug addicts

Abstract

Background. Chronic drug intoxication accompanied by deep progressive disorders of exchange with the subsequent formation of endotoxemia and development of organ pathology. Strengthening of anti-oxidant protection is important in breaking of this pathogenetic chain. In order to increase the activity of antioxidant enzymes, depending on the presence in their structure of bio-elements, into the standard treatment of addition of cuprum and selenium (in biologically active additives composition). Methods. Of the 120 men 18-40 years with a syndrome of opioid dependence have formed 4 groups of 30 persons: 1^st - experimental group (baseline), 2^nd - the standard treatment, 3^rd - the standard treatment with the addition of cuprum, 4^th - the standard treatment with the addition of selenium. Control - healthy men 18-28 years. In the blood of patients, determined the concentration of malondialde-hyde, activity of antioxidant enzymes, level of bio-elements and level of average weight molecules. Results. In the blood, drug addicts found elevated levels of malondialdehyde, a significant decrease in the activity of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase-tionperoksidazy - 41, 21, 79, 42%, decrease of levels of selenium (50%) and cuprum (97%), increasing the concentration of average weight molecules. Addition to the standard treatment of cuprum and sele-nium increased the level of cuprum by 85.7%, selenium - 60%. Combined use of standard treatment and copper achieve a significant increase in the levels of enzymes studied at 23, 12,97 and 41% selenium - 10, 11, 83 and 15%. Number of malondialdehyde decreased by 20%, reduced the level of average weight molecules. More pronounced effect was observed with using cuprum. Conclusions. In chronic drug intoxication develop serious violations in system “free radical oxidation - antioxidant protection”. Standard therapy has no effect on this drug dependence pathogenetic link. Addition to complex treatment bioelemets (Cu, Se) physiological concentration of which provides the metal-dependent antioxidant enzymes, allow significantly increase the activity of the leading factors of antioxidant protection.