Clinical efficiency of long-term use of amlodipine in the treatment of arterial hypertension in postmenopausal women

Abstract

Background. Arterial hypertension (AH) in Russia is the leader in cardiovascular morbidity and an important predictor of disability and mortality of the adult population. Methods. The study included 30 patients with hypertension, amlodipine 5-10 mg / day for 36 weeks. Conducted daily monitoring of blood pressure (BP), echocardiography, Holter monitoring electrocardiogram, body sphygmography. Results. Statistically significant reduction in average daily, average nighttime systolic and diastolic blood pressure, decreased pulse pressure in the daytime and nighttime. The number of patients with physiological night BP reduction increased from 36.7 to 60%. The treatment resulted in a reduction of vascular remodeling of elastic and muscular type, reduce their structural changes. Amlodipine helped to improve left ventricular diastolic function. Statistically significant normalization of diastolic indicators was accompanied by decrease in the volume of the left atrium and the regression of cardiac hypertrophy (decrease myocardial mass index and relative left ventricular wall thickness by 9.6 and 8.7%, respectively). Conclusions. The results of our study showed beneficial effects of amlodipine on the process of ventricular repolarization. In women with hypertension in postmenopausal amlodipine slowed the progression of cardiovascular remodeling, lead to normalization of the circadian rhythm of blood pressure and helped stabilize the electro-physiological properties of the myocardium.