Molecular mechanisms of cellular protection in reconstructive-regenerative surgery of the main arteries
Abstract
Background. At the existing tendency to morbidity growth and increase of prevalence of risk factors of the obliterating atherosclerosis of the lower limbs the improving of conservative methods of treatment is more and more actual. As the important components of this direction are the correction of the endothelial dysfunction and stimulation of the neoangiogenesis. Methods. 40 patients with acute and chronic ischemia of the lower limbs due to the obliterating atherosclerosis were examined. The stress-induced system indicators - nitrogen oxide, thermal shock proteins, endothelial factor of growth, Bcl-2 proteins - after reconstructive-regenerative surgeries on the main arteries and without them (control group) - were studied. Results. The level of the thermal shock proteins and the nitrogen oxide metabolits in patients’ blood after the surgical treatment has decreased. The pilot studying of neoangiogenesis markers has shown the significant change of the endothelial growth factor comparing with the control group. Conclusions. The revealed authentic tendencies in change of stress-inducible system indicators prove their direct influence on the mechanisms of immediate and long-term adaptation to ischemic stress and reperfusive answer in the postoperative period.
About the Authors
R. E. Kalinin
Ryazan State Medical University named by academician I.P. Pavlov
Russian Federation
Russian Federation
A. S. Pshennikov
Ryazan State Medical University named by academician I.P. Pavlov
Russian Federation
Russian Federation
I. A. Suchkov
Ryazan State Medical University named by academician I.P. Pavlov
Russian Federation
Russian Federation
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Review
For citations:
Kalinin R.E., Pshennikov A.S., Suchkov I.A. Molecular mechanisms of cellular protection in reconstructive-regenerative surgery of the main arteries. Pacific Medical Journal. 2014;(3):52-55. (In Russ.)
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