The condition of the phoshpor-calcium exchange at children with caries

Abstract

Background. The WHO has included teeth caries in the six illnesses of the present which prophylaxis is the most actual problem of a medical science and public health services. Methods. For the purpose of the complex analysis of the condition of phosphor-calcium exchange at children with caries the examination of 104 patients of 7-14 years old with compensated and subcompensated disease forms (the basic group) and 20 healthy children with intact teeth (control group) was done. The research material was the blood serum and mixed non-stimulated saliva in which the concentration of the general and ionized calcium and inorganic phosphate were estimated. In blood serum also the level of calcitonin, osteocalcin, parat hormone and 25-hydroxy vitamin D₃ was calculated. Results. In blood serum of all patients the maintenance of the general calcium and phosphorus was within reference limits. However at children with caries requiring therapy the relative insufficiency of the general calcium and statistically significant decrease in the ratio of the ionized calcium and inorganic phosphorus are revealed. The concentration of the ionized calcium in saliva was significantly higher at children requiring sanitation of teeth. At them considerable change of the ratio “calcium: phosphorus” is found. At all children with caries the hyperproduction of osteocalcin and decreased level of 25-hydroxy vitamin D₃, the direct moderate correlation between calcitonin level and 25-hydroxy vitamin D₃ is revealed. At complex treatment by calcium and vitamin D₃ in 6 months there was statistically significant increase in blood of the general and ionized calcium and 25-hydroxy vitamin D₃ and also normalized the local level of calcium and its ratio to phosphorus. Conclusions. Infringement in calcium-phosphoric balance leads to the mineralization lesion of enamel and reduces the resistance of the tooth tissues to adverse influence of the oral liquid. Treatment of children with subcompensated caries of the combined calcium preparation leads to the normalization of phosphor-calcium exchange.