УГЛЕВОДНЫЕ БИОПОЛИМЕРЫ ДЛЯ АДРЕСНОЙ ДОСТАВКИ БЕЛКОВЫХ ПРЕПАРАТОВ, НУКЛЕИНОВЫХ КИСЛОТ И ПОЛИСАХАРИДОВ
Аннотация
Статья посвящена новому научному направлению -разработке систем адресной доставки белков, нуклеиновых кислот и полисахаридов через тканевые барьеры. Внимание уделено природным нетоксичным соединениям, составляющим группу углеводных биополимеров. Описаны структура, физико-химические свойства и фармакологическая активность пектинов, альгинатов, хитозанов, каррагинанов и фукоиданов и микро- и наносистем на основе этих соединений. Приведены примеры использования наночастиц хитозана для энтерального введения гормонов, генов эритропоэтина и гепарина. Подчеркнута необходимость проведения токсикологических исследований новых лекарственных форм.
Об авторе
Ю. С. Хотимченко
Институт биологии моря им. А.В. Жирмунского ДВО РАН; Дальневосточный федерального университета; Тихоокеанский государственный медицинский университет
Россия
Россия
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Для цитирования:
Хотимченко Ю.С. УГЛЕВОДНЫЕ БИОПОЛИМЕРЫ ДЛЯ АДРЕСНОЙ ДОСТАВКИ БЕЛКОВЫХ ПРЕПАРАТОВ, НУКЛЕИНОВЫХ КИСЛОТ И ПОЛИСАХАРИДОВ. Тихоокеанский медицинский журнал. 2014;(2):5-13.
For citation:
Khotimchenko Yu.S. CARBOHYDRATE BIOPOLYMERS FOR TARGETED DELIVERY OF PROTEIN DRUGS, NUCLEIC ACIDS AND POLYSACCHARIDES. Pacific Medical Journal. 2014;(2):5-13. (In Russ.)
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