CARBOHYDRATE BIOPOLYMERS FOR TARGETED DELIVERY OF PROTEIN DRUGS, NUCLEIC ACIDS AND POLYSACCHARIDES
Abstract
The article is devoted to a new scientific direction - development of systems for the specific delivery of proteins, nucleic acids and polysaccharides through tissue barriers. Attention is given to natural, non-toxic compounds constituting a group of carbohydrate biopolymers. The paper also describes the structure, physicochemical properties and pharmacological activity of pectins, alginates, chitosans, carrageenans, fucoidans and micro- and nanosystems based on these compounds. The author gives examples of the use of chitosan nanoparticles for enteral introduction of hormones, genes erythropoietin and heparin. The emphasis is put on the necessity for toxicological studies of new drug dosage forms.
About the Author
Yu. S. Khotimchenko
Institute of Marine Biology named after A.V. Zhirmunskiy FEB RAS; Far Eastern Federal University; Pacific State Medical University
Russian Federation
Russian Federation
References
1. Оводов Ю.С. Современные представления о пектиновых веществах // Биоорганическая химия. 2009. Т. 35, № 3. С. 293-310.
2. Хотимченко Ю.С., Хасина Э.И., Ковалев В.В. [и др.]. Эффективность пищевых некрахмальных полисахаридов при экспериментальном токсическом гепатите // Вопросы питания. 2000. Т. 69, № 1-2. С. 22-26.
3. Adhikari U., Mateub C.G., Chattopadhyaya K.C. [et al.]. Structure and antiviral activity of sulfated fucans from Stoechospermum marginatum // Phytochemistry. 2006. Vol. 67. P. 2474-2482.
4. D’Ayala G.G., Malinconico M., Laurienzo P. Marine derived polysaccharides for biomedical applications: chemical modification approaches // Molecules. 2008. Vol. 13. P. 2069-2106.
5. Bowman K., Sarkar R. Raut S., Leong K.W. Gene transfer to hemophilia A mice via oral delivery of F VIII-chitosan nanoparticles // J. Control. Release. 2008. Vol. 132. P. 252-259.
6. Caffall K.H., Mohnen D. The structure, function, and biosynthesis of plant cell wall pectic polysaccharide // Carbohydr. Res. 2009. Vol. 344. P. 1879-1900.
7. Chen J., Yang W.L., Li G. [et al.]. Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles // World J. Gastroenterol. 2004. Vol. 10. P. 112-116.
8. Chen M.C., Wong H.S., Lin K.J. [et al.]. The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin // Biomaterials. 2009. Vol. 30. P. 6629-6637.
9. Cicala C., Morello S., Alfieri A. [et al.]. Haemostatic imbalance following carrageenan-induced rat paw oedema // Eur. J. Pharmacol. 2007. Vol. 577. P. 156-161.
10. Cui F., QianF., Zhao Z. [et al.]. Preparation, characterization, and oral delivery of insulin loaded carboxylated chitosan grafted poly (methylmethacrylate) nanoparticles // Biomacromolecules. 2009. Vol. 10. P. 1253-1258.
11. Florence A.T. Nanoparticle uptake by the oral route: fulfilling its potential? // Drug Discov. Today. 2005. Vol. 2. P. 75-81.
12. Ishii T., Okahata Y., Sato T. Mechanism of cell transfection with plasmid/chitosan complexes // Biochim. Biophys. Acta. 2001. Vol. 1514. P. 51-64.
13. Kadiyala I., Loo Y., Roy K. [et al.]. Transport of chitosan-DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes // Eur. J. Pharm. Sci. 2010. Vol. 39. P. 103-109.
14. Khotimchenko M., Kovalev V., Khotimchenko Y.S. Comparative equilibrium studies of sorption of Pb (II) ions by sodium and calcium alginate // Journal of Environmental Sciences. 2008. Vol. 20. P. 827-831.
15. Khotimchenko M.Y., Kolenchenko E.A., Khotimchenko Y.S. [et al.]. Cerium binding activity of different pectin compounds in aqueous solutions // Colloids Surf. B. Biointerfaces. 2010. Vol. 77. P. 104-110.
16. Khotimchenko M.Y., Kolenchenko E.A., Khotimchenko Y.S. Zinc-biding activity of different pectin compounds in aqueous solutions // Journal of Colloid and Interface Science. 2008. Vol. 323. P. 216-222.
17. Khotimchenko M., Serguschenko I., Khotimchenko Y.S. Lead absorption and excretion in rats given insoluble salts of pectin and alginate // Int. J. Toxicol. 2006. Vol. 25. P. 195-203.
18. Khotimchenko Y.S., Khotimchenko M.Y. Healing and preventive effects of calcium alginate on carbon tetrachloride induced liver injury in rats // Mar. Drugs. 2004. Vol. 2. P. 108-122.
19. Kim S.K., Vaishali B., Lee E. [et al.]. Oral delivery of chemical conjugates of heparin and deoxycholic acid in aqueous formulation // Thromb. Res. 2006. Vol. 117. P. 419-427.
20. Laurienzo P. Marine polysaccharides in pharmaceutical applications: An Overview // Mar. Drugs. 2010. Vol. 8. P. 2435-2465.
21. Lee K.W., Jeong D., Na K. Doxorubicin loading fucoidan acetate nanoparticles for immune and chemotherapy in cancer treatment // Carbohydr. Polym. 2013. Vol. 94. P. 850-856.
22. Lewis J.G., Stanley N.F., Guist G.G. Commercial production and applications of algal hydrocolloids // Algae and Human Affairs. Cambridge: University Press, 1988. P. 205-236.
23. Li B., Lu F., Wei X., Zhao R. Fucoidan: structure and bioactivity // Molecules. 2008. Vol. 13. P. 1671-1695.
24. Lira M.C., Santos-Magalhães N.S., Nicolas V. [et al.]. Cytotoxicity and cellular uptake of newly synthesized fucoidan-coated nanoparticles // European Journal of Pharmaceutics and Biopharmaceutics. 2011. Vol. 79. P. 162-170.
25. Martien R., Loretz B., Thaler M. [et al.]. Chitosan-thioglycolic acid conjugate: an alternative carrier for oral nonviral gene delivery? // Journal of Biomedical Materials Research. 2007. Vol. 82. P. 1-9.
26. Mi F.L., Wu Y.Y., Lin Y.H. [et al.]. Oral delivery of peptide drugs using nanoparticles self-assembled by poly(γ-glutamic acid) and a chitosan derivative functionalized by trimethylation // Bioconjug. Chem. 2008. Vol. 19. P. 1248-1255.
27. Morris G., Kök S., Harding S., Adams G. Polysaccharide drug delivery systems based on pectin and chitosan // Biotechnol. Gen. Eng. Rev. 2010. Vol. 27. P. 257-284.
28. Prego C., Torres D., Fernandez-Megia E. [et al.]. Chitosan-PEG nanocapsules as new carriers for oral peptide delivery: effect of chitosan PEGylation degree // J. Control. Release. 2006. Vol. 111. P. 299-308.
29. Pomin V.H., Mouräo PA.S. Structure, biology, evolution, and medical importance of sulfated fucans and galactans // Glycobiology. 2008. Vol. 18. P. 1016-1027.
30. Rinaudo M. Chitin and chitosan: Properties and applications // Prog. Polym. Sci. 2006. Vol. 31. P. 603-632.
31. Sarmento B., Ribeiro A. Veiga F. [et al.]. Alginate/chitosan nanoparticles are effective for oral insulin delivery // Pharm. Res. 2007. Vol. 24. P. 2198-2206.
32. Shahidi F., Abuzaytoun R. Chitin, chitosan, and co-products: chemistry, production, applications, and health effects // Adv. Food Nutr. Res. 2005. Vol. 49. P. 189-195.
33. Sadeghi A., Dorkoosh F., Avadi M. [et al.]. Permeation enhancer effect of chitosan and chitosan derivatives: comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells // Eur. J. Pharm. Biopharm. 2008. Vol. 70. P. 270-278.
34. Shibata H., Kimura-Takagi I., Nagaoka M. [et al.]. Inhibitory effect of Cladosiphon fucoidan on the adhesion of Helicobacter pylori to human gastric cells // Journal of Nutritional Science and Vitaminology. 1999. Vol. 45. P. 325-336.
35. Sonaje K., Chen Y.J. Chen H.L. [et al.]. Enteric-coated capsules filled with freeze-dried chitosan/poly ([gamma]-glutamic acid) nanoparticles for oral insulin delivery // Biomaterials. Vol. 2010. Vol. 31. P. 3384-3394.
36. Sonaje K., Chuang E.Y., Lin K.J. [et al.]. Opening of epithelial tight junctions and enhancement of paracellular permeation by chitosan: microscopic, ultra-structural and computed-tomographic observations // Molecular Pharmacology. 2012. Vol. 9. P. 1271-1279.
37. Sonaje K., Lin Y.H., Juang J.H. [et al.]. In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery // Biomaterials. 2009. Vol. 30. P. 2329-2339.
38. Sonaje K., Lin K.J., Tseng M.T. [et al.]. Effects of chitosan-nano-particle-mediated tight junction opening on the oral absorption of endotoxins // Biomaterials. 2011. Vol. 32. P. 8712-8721.
39. Szayna M., Doyle M.E., Betkey J.A. [et al.]. Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats // Endocrinology. 2000. Vol. 141. P. 1936-1941.
40. Tsukita S., Furuse M. Pores in the wall: claudins constitute tight junction strands containing aqueous pores // J. Cell Biol. 2000. Vol. 149. P. 13-16.
41. Wong T.W., Colombo G., Sonvico F. Pectin matrix as oral drug delivery vehicle for colon cancer treatment // AAPS PharmSciTech, 2011. Vol. 12, No. 1. P. 201-214.
42. Wong T.W. Alginate graft copolymers and alginate-co-excipient physical mixture in oral drug delivery // J. Pharm. Pharmacol. 2011. Vol. 63. P. 1497-1512.
43. Yeh T.H., Hsu L.W., Tseng M.T. [et al.]. Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening // Biomaterials. 2011. Vol. 32. P. 6164-6173.
44. Yermak I.M., Khotimchenko Yu.S. Chemical properties, biological activities and applications of carrageenans from red algae // Recent Advanced Marine Biotechnoly. 2003. Vol. 9. P. 207-255.
45. Yin L., Ding J., He C. Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery // Biomaterials. 2009. Vol. 30. P. 5691-5700.
Review
For citations:
Khotimchenko Yu.S. CARBOHYDRATE BIOPOLYMERS FOR TARGETED DELIVERY OF PROTEIN DRUGS, NUCLEIC ACIDS AND POLYSACCHARIDES. Pacific Medical Journal. 2014;(2):5-13. (In Russ.)
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