THE ROLE OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN DEVELOPMENT OF MICROHEMOCIRCULATORY MALFUNCTIONS OF THE RESPIRATORY SYSTEM OF THE NEPHROLOGICAL PATIENTS
Abstract
Though for the time being the role of the renin-angiotensin-aldosterone system (RAAS) in development of the sclerotic processes associated with the chronic kidney disease results in a considerable attention, the formation of fibrosis in the respiratory system still remains understudied. Methods. The study examines 80 patients having the chronic kidney disease. With the use of radioimmunoassay determined the concentration of aldosterone and angiotensin I in serum, studied biopsies of bronchial mucosa. Results. Detected a significant increase in the concentration of angiotensin I in all grades and of aldosterone from 4 to 5 grades of the chronic kidney disease. Subject to the severity of the illness a variety of changes in bronchi aggravated, i.e. deformation of the microvascular channels, metaplasia and atrophy of the ciliated epithelium and mucosal sclerosis until further formation of the full clinical presentation of the persisting secondary bilateral diffuse endobronchitis. Conclusions. An excessive activation of the renin-angiotensin-aldosterone system in case of the chronic kidney disease is a priority-driven factor of development of the microhemocirculatory malfunctions. The RAAS has the vasoconstrictive and fiber generating effects in the early grades while its effects associated with the mineralocorticoid aldosterone influence are revealed in the final grades.
About the Authors
N. A. Shcherban
I.P. Pavlov St. Petersburg State Medical University
Russian Federation
Russian Federation
S. S. Tseluiko
Amur State Medical Academy
Russian Federation
Russian Federation
Y. S. Landyshev
Amur State Medical Academy
Russian Federation
Russian Federation
References
1. Бобкова И.Н., Козловская Л.В., Рамеева А.С. и др. Клиническое значение определения в моче маркеров эндотелиальной дисфункции и факторов ангиогенеза в оценке тубулоинтерстициального фиброза при хроническом гломерулонефрите // Тер. архив. 2007. № 6. С.10-15.
2. Kasacka I., Pilat-Marcinkiewicz B., Pankiewicz W. [et al.]. Morphological evaluation of the lungs in rats with experimentally induced renal failure // Rocz. Akad. Med. Bialymst. 2004. Vol. 49, No. 1. P. 204-206.
3. Li X.C., Klahr S., Morrissey J.J. The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease // Kidney Int. 2000. Vol. 57, No. 75. P. 7-14.
4. Li X.C., Zhuo J.L. Nuclear factor-kappaB as a hormonal intracellular signaling molecule: focus on angiotensin II-induced cardiovascular and renal injury // Curr. Opin. Nephrol. Hypertens. 2008. Vol. 17, No. 1. P. 37-43.
5. Ruiz-Ortega M., Ruperez M., Lorenzo O. [et al.] Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney // Kidney Int. 2002. Vol. 82. P. 12-22.
6. Ruiz-Ortega M., Lorenzo O., Suzuki Y. [et al.] Proinflammatory actions of angiotensin II // Curr. Opin. Nephrol. Hypertens. 2001. Vol. 10. P. 321-329.
7. Ruperez M., Sanchez-Lopez E., Blanco-Colio L.M. [et al.]. The Rho-kinase pathway regulates angiotensin II-induced renal damage // Kidney Int. 2005. Vol. 99. P. 39-45.
8. Schlondorf D. The role of chemokines in the initiation and progression of renal disease // Kidney Int. 1995. Vol. 47. P. 44-47.
9. Schneider A., Panzer U., Zahner G. [et al.]. Monocyte chemoat-tractant protein-1 mediates collagen deposition in experimental glomerulonephritis by transforming growth factor-b // Kidney Int. 1999. Vol. 56. P. 135-144.
10. Wolf G. Angiotensin II: a pivotal factor in the progression of renal disease // Nephrol. Dial. Transplant. 1999. Vol. 14, No. 1. P. 42-44.
11. Wolf G. Molecular mechanisms of angiotensin II in the kidney: emerging role in the progression of renal disease: beyond haemodynamics // Nephrol. Dial. Transplant. 1998. Vol. 13. P. 1131-1142.
12. Wolf G., Ziyadeh F.N., Thaiss F. et al. Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells // Clin. Invest. 1997. Vol. 100. P. 1047-1058.
Review
For citations:
Shcherban N.A., Tseluiko S.S., Landyshev Y.S. THE ROLE OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN DEVELOPMENT OF MICROHEMOCIRCULATORY MALFUNCTIONS OF THE RESPIRATORY SYSTEM OF THE NEPHROLOGICAL PATIENTS. Pacific Medical Journal. 2014;(1):78-81. (In Russ.)
Views:
285
Email this article 