NEUROTRANSMITTER ROLE OF AGMATINE, ITS INTERACTION WITH CLASSIC NEUROMEDIATORS AND CONTRIBUTION TO MECHANISM OF PAIN DEVELOPMENT
Abstract
The paper reviews the literature data and in-house researches on neurotransmitter agmatine and distribution of agmatinase defined as the agmatine-degrading enzyme in mammalian and human brain. The in-house studies are indicative of agmatinase known to occur in spinal and supraspinal motoneurons, cortical interneurons and hippocampal interneurons. The agmatinergic neurons are lacking in the posterior horn of the spinal cord. The immunocytochemical agmatinase is found in this region on neuron body and process. The authors have identified a population of initially sensitive neurons in spinal ganglions known to change the activity level, given the inflammatory and neuropathic pain. The agmatinase has been found in a small population of large neurons of rostral ventromedial medulla that formed part of endogenous monoamine analgesic systems in brain. The literature data analysis allows supposing that the antinociceptive action of agmatine arises from its rather close relationship with nitroxidergic and monoamine systems in brain and spinal cord.
About the Authors
I. V. Dyuizen
Pacific State Medical University
Russian Federation
Russian Federation
T. V. Balashova
Pacific State Medical University
Russian Federation
Russian Federation
N. E. Lamash
Institute of Marine Biology named after A.V. Zhirmunsky
Russian Federation
Russian Federation
L. A. Mnatsakanyan
Pacific State Medical University
Russian Federation
Russian Federation
V. B. Shoumatov
Pacific State Medical University
Russian Federation
Russian Federation
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Dyuizen I.V., Balashova T.V., Lamash N.E., Mnatsakanyan L.A., Shoumatov V.B. NEUROTRANSMITTER ROLE OF AGMATINE, ITS INTERACTION WITH CLASSIC NEUROMEDIATORS AND CONTRIBUTION TO MECHANISM OF PAIN DEVELOPMENT. Pacific Medical Journal. 2013;(4):22-27. (In Russ.)
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