CYTOKINE PROFILE IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH HYPERCHOLESTEROLEMIA
Abstract
The paper studies lipid spectrum, levels of tumour necrosis factor beta and in-terleukins-1b and 10 in women with rheumatoid arthritis with hypercholesterolemia. The authors have examined 98 patients, including 72 women with rheumatoid arthritis associated with mild and moderate forms of hypercholesterolemia, without clinical manifestations of cardiovascular pathology, and 26 almost healthy women (control group). In all cases of rheumatoid arthritis the authors detected increased levels of atherogenic blood lipid fractions (low-density lipoproteins and triglycerides) and considerably increased content of tumour necrosis factor-beta and inter-leukin-1b in blood serum that confirmed high activity of chronic immune inflammation and risk for cardiovascular complications.
About the Authors
N. S. Komendantova
Primorsky Krai Regional Clinical Hospital No. 1; Pacific State Medical University
Russian Federation
Russian Federation
Yu. V. Kulakov
Pacific State Medical University
Russian Federation
Russian Federation
A. A. Sinenko
Pacific State Medical University
Russian Federation
Russian Federation
P. A. Lukyanov
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS
Russian Federation
Russian Federation
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Review
For citations:
Komendantova N.S., Kulakov Yu.V., Sinenko A.A., Lukyanov P.A. CYTOKINE PROFILE IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH HYPERCHOLESTEROLEMIA. Pacific Medical Journal. 2013;(3):47-48. (In Russ.)
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