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ROLE OF DEEP BRAIN STRUCTURES IN OCCURRING EPILEPTIC DISCHARGE

Abstract

The paper provides analysis of values of videoelectroencephalographic monitoring during sleep of patient with idiopathic generalised tonic-clonic seizures. The electroencephalogram of the second stage of deep sleep demonstrates generalised epileptiform activity that occurs independently of the ‘sleep spindles’ and detects that the structure of ‘sleep spindles’ is kept even when the epileptiform pattern is being recorded. These facts prove to be inconsistent with the key thalamocortical relationship theory postulate, which is a transformation of ‘sleep spindles’ into ‘spike-wave’ and ‘sharp-slow wave’ complexes. The case follow-up reliably confirms that the rhythms of high amplitude ‘spike-wave’ and ‘sharp-slow wave’ complexes known to occur in the electroencephalograms of patients with idiopathic generalised epilepsy are only a cortical phenomenon likely to be caused by ‘sleep spindles’ activity. The incitation spreads by cortical structures, only.

About the Author

S. A. Gulyaev
Pacific State Medical University
Russian Federation


References

1. Полыковский М.Г., Добронравов С.Н. Электроэнцефалография при кожевниковской эпилепсии // Ж. невропатологии и психиатрии. 1952. Т. 2, вып. 5. С. 47-49.

2. Avoli M., Gloor P., Kostopoulos G., Gotman J. An analysis of penicillin-induced generalized spike-and-wave discharges using simultaneous recording of cortical and thalamic single units // J. Neurophysiol. 1983. Vol. 50. P. 819-837.

3. Crunelli V, Leresche N. Childhood absence epilepsy: genes, channels, neurons and networks // Nat. Rev. Neurosci. 2002. Vol. 3. P. 371-382.

4. Gloor P. Generalised cortico-reticular epilepsies. Some considerations on the pathophysiology of generalised bilaterally synchronous spike and wave discharge // Epilepsia. 1968. Vol. 9. P. 249-263.

5. Jackson J.H. Epileptic attacks in a patient who had symptoms pointing to gross organic disease of the right temporosphenoidal lobe // Brain. 1899. Vol. 22. P. 534-549.

6. Kostopoulos G., Gloor P., Pellegrini A., Siatitsas I. A study of the transition from spindles to spike and wave discharge in feline generalized penicillin epilepsy: EEG features // Exp. Neurol. 1981. Vol. 73. P. 43-54.

7. Leresche N., Lambert R.C., Errington A.C., Crunelli V. From sleep spindles of natural sleep to spike and wave discharges of typical absence seizures: is the hypothesis still valid? // Pflugers Arch. -Eur. J. Physiol. 2012. Vol. 463. P. 201-212.

8. Penfield W., Jasper H. Epilepsy and the functional anatomy of the human brain. Boston: Little, Brown & Co, 1954. 204 p.

9. Smyk M.K., Coenen A.M., Lewandowski M.H., van Luijtelaar G. Endogenous rhythm of absence epilepsy: relationship with general motor activity and sleep-wake states // Epilepsy Res. 1993. P. 120-127.


Review

For citations:


Gulyaev S.A. ROLE OF DEEP BRAIN STRUCTURES IN OCCURRING EPILEPTIC DISCHARGE. Pacific Medical Journal. 2013;(3):91-94. (In Russ.)

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ISSN 1609-1175 (Print)