PECTIN-BASED BIOCOMPATIBLE DEGRADABLE MATERIALS FOR TISSUE ENGINEERING: LOCAL TISSUE REACTION AFTER SUBCUTANEOUS IMPLANTATION
Abstract
The paper presents the results of histological evaluation of local tissue reaction after subcutaneous implantation of biopolymer matrix materials made of modified pectin and collagens of various types. No acute inflammation or rejection were produced. Loose fibrous capsule was formed around the implants. The capsule decreased and disappeared three months after polysaccharide matrix implantation. Cells and blood vessels infiltrated the implants. Matrix slowly degraded. Composite matrix made of citrus modified pectin (with the degree of esterification 30 %), collagen I and NC1-hexamer of collagen IV was partially preserved three months after the subcutaneous implantation while collagen sponge was fully resorbed during one month. The data lay the foundation for the elaboration of new slowly degradable biomaterials for tissue engineering.
About the Authors
A. V. Shcheblykina
A.V. Zhirmunsky Institute of Marine Biology; Far Eastern Federal University
Russian Federation
Russian Federation
P. V. Mishchenko
A.V. Zhirmunsky Institute of Marine Biology; Far Eastern Federal University
Russian Federation
Russian Federation
V. V. Kumeiko
A.V. Zhirmunsky Institute of Marine Biology; Far Eastern Federal University
Russian Federation
Russian Federation
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Review
For citations:
Shcheblykina A.V., Mishchenko P.V., Kumeiko V.V. PECTIN-BASED BIOCOMPATIBLE DEGRADABLE MATERIALS FOR TISSUE ENGINEERING: LOCAL TISSUE REACTION AFTER SUBCUTANEOUS IMPLANTATION. Pacific Medical Journal. 2013;(2):13-17. (In Russ.)
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