PROTECTIVE ACTION OF AMARANTH PECTIN IN GASTROPATHY INDUCED NONSTEROIDAL ANTI-FLAMMATORY DRUGS
Abstract
The protective effect of amaranth pectin from Amaranthus cruenthus L. (fam. Amaranthaceae) against damage of the stomach induced by nonsteroidal anti-flammatory drugs (NSAIDs) indomethacin and meloxicam in male Wistar rats was studied. Oral administration of amaranth pectin (100 mg/kg) prevented gastric injury formation. The data obtained demonstrated that amaranth pectin enhances resistance of the stomach tissue to NSAIDs. It was shown to possess a gastroprotective effect, which is accompanied by diminution of the number and sizes of destructive regions in the gastric mucosa during the ulcer affection, as well as reduction of ATP and glycogen deficit, decrease of lactate excess, and normalization of the energy balance in the gastric tissue. According to its antiulcer effect, amaranth pectin may be recommended for application in prevention and treatment of stomach diseases together with the basic therapy.
About the Authors
E. I. Khasina
V.L. Komarov Gornotayozhnaya Station FEB RAS
Russian Federation
Russian Federation
L. I. Moiseenko
V.L. Komarov Gornotayozhnaya Station FEB RAS Vladivostok State University of Economics and Service
Russian Federation
Russian Federation
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Review
For citations:
Khasina E.I., Moiseenko L.I. PROTECTIVE ACTION OF AMARANTH PECTIN IN GASTROPATHY INDUCED NONSTEROIDAL ANTI-FLAMMATORY DRUGS. Pacific Medical Journal. 2013;(2):18-21. (In Russ.)
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