A DOSE-DEPENDENT ANALGESIC EFFECT OF DOCOSAHEXAENOIC ACID IN CASE OF EXPERIMENTAL PERIPHERAL NEUROPATHY
Abstract
The experiment on white rats confirms that the sciatic nerve ligation causes neuropathic pain syndrome characterised by a decrease in the temperature pain threshold, uneven weight distribution on hind-limbs, and dystrophic changes in foot tissues. Depending on dose used to treat animals with sciatic nerve injury, the docosahexaenoic acid reduces the intensity and period of neuropathic pain syndrome and allows earlier stabilisation of weight distribution, thus hindering the dystrophic changes in foot tissues.
About the Authors
I. V. Manzhoulo
A.V. Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences; Pacific State Medical University
Russian Federation
Russian Federation
I. V. Dyuizen
A.V. Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences; Pacific State Medical University
Russian Federation
Russian Federation
O. S. Ogourtsova
A.V. Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences; Pacific State Medical University
Russian Federation
Russian Federation
N. E. Lamash
A.V. Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences; Far Eastern Federal University
Russian Federation
Russian Federation
N. A. Latyishev
A.V. Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
S. V. Kasyanov
A.V. Zhirmunsky Institute of Marine Biology of the Far Eastern Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. A. Tyurtyishnaya
Far Eastern Federal University
Russian Federation
Russian Federation
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Review
For citations:
Manzhoulo I.V., Dyuizen I.V., Ogourtsova O.S., Lamash N.E., Latyishev N.A., Kasyanov S.V., Tyurtyishnaya A.A. A DOSE-DEPENDENT ANALGESIC EFFECT OF DOCOSAHEXAENOIC ACID IN CASE OF EXPERIMENTAL PERIPHERAL NEUROPATHY. Pacific Medical Journal. 2013;(2):31-33. (In Russ.)
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