INTEGRATION OF CLINICAL PHARMACOLOGY SERVICE AND MEDICAL GENETICS AS ONE OF THE STAGES OF PHARMACOLOGICAL SURVEILLANCE IN PREGNANT WOMEN
Abstract
The frequency of innate anomalies throughout the world varies and to a greater extent depends on the surveillance system management. The prevention of foetal congenital anomalies during preconception, prenatal and postnatal stages is a top-priority target of the health care service. Analysing the pharmacotherapy of 1306 pregnant women in Primorsky Krai in 2004-2010, the authors concluded that the medications were being prescribed during the first and the second critical periods. Only 27.94 % of prescribed medications were relatively safe for foetus (А, В FDA categories). In 36.12 % of cases these were drugs of unascertained safety (N FDA category). In 35.94 % cases the doctors prescribed medications known for their risks for teratogenic and embryotoxic properties (C, D, X FDA categories). As reported, the joint efforts of genetics and clinical pharmacologists allow to increase the safety in prescribing medications for pregnant women.
About the Authors
Yu. V. Feoktistova
Pacific State Medical University
Russian Federation
Russian Federation
E. A. Poddoubniy
Pacific State Medical University
Russian Federation
Russian Federation
I. I. Shmyikova
Pacific State Medical University
Russian Federation
Russian Federation
S. V. Voronin
Regional Clinical Centre of Specialised Medical Care
Russian Federation
Russian Federation
B. I. Geltser
Pacific State Medical University; Vladivostok State University of Economics and Service
Russian Federation
Russian Federation
References
1. Баранов В.С., Кузнецова Т.В. Цитогенетика эмбрионального развития человека. СПб.: Н-Л, 2007. 288 с.
2. Безопасность фармакотерапии у беременных / Е.В. Елисеева, Ю.В. Феоктистова, И.И. Шмыкова. 3-е изд., перераб. и доп. Владивосток: Медицина ДВ, 2012. 108 с.
3. Борьба с наследственными болезнями [пер. с англ.]: доклад научной группы ВОЗ / Серия технических докладов ВОЗ. М.: Медицина, 1997. № 865. 134 с.
4. Елисеева Е.В., Поддубный Е.А., Воронин С.В. и др. Опыт совместной работы служб клинической фармакологии и медицинской генетики // Проблемы стандартизации в здравоохранении. 2011. № 9-10. С. 17-23.
5. Елисеева Е.В., Поддубный Е.А., Воронин С.В. и др. Применение лекарственных средств у беременных в Приморском крае: ретроспективный анализ // Тихоокеанский медицинский журнал. 2011. №1. С. 79-82.
6. Заболевания легких при беременности / под ред. А.Г. Чучалина, В.И. Краснопольского, Р.С. Фассахова. М: Атмосфера, 2002. 88 с.
7. Стриженок Е.А., Гудков Л.С. Страчунский Л.С. Применение лекарственных средств при беременности: результаты многоцентрового фармакоэпидемиологического исследования // Клин. микробиол. антимикроб. химиотер. 2007. Т. 9, № 2. С. 162-175.
8. Rohra D.K., Das N., Azam S.I. et al. Drug-prescribing patterns during pregnancy in the tertiary care hospitals of Pakistan: a cross sectional study // BMC Pregnancy and Childbirth. 2008. Vol. 8. P. 24. URL: http://www.biomedcentral.com/1471-2393/8/24 (дата обращения 12.08.2010).
9. Sharma R., Kapoor B., Verma U. Drug utilization pattern during pregnancy in North India // Indian. J. Med. Sci. 2006. Vol. 60, No. 7. P. 277-287. URL: http://www.indianjmedsci.org/article. asp?issn=0019-5359;year=2006;volume=60;issue=7;spage=277; epage=287;aulast=Sharma (дата обращения 8.08.2010).
10. Scheinfeld N.S., Allan J.M., Davis A. Teratology and Drug Use During Pregnancy. Updated: Apr 27, 2009. URL: http:// www.emedicine.com/med/topic3242.htm (дата обращения 12.03.2011).
Review
For citations:
Feoktistova Yu.V., Poddoubniy E.A., Shmyikova I.I., Voronin S.V., Geltser B.I. INTEGRATION OF CLINICAL PHARMACOLOGY SERVICE AND MEDICAL GENETICS AS ONE OF THE STAGES OF PHARMACOLOGICAL SURVEILLANCE IN PREGNANT WOMEN. Pacific Medical Journal. 2013;(2):43-46. (In Russ.)
Views:
244
Email this article 