THE PHENOMENON OF DIRECTED MAMMALIAN STEM CELL MIGRATION TOWARD AN EXPERIMENTAL GLIOBLASTOMA SITE AS A BASIS OF INNOVATIVE ANTITUMOR TECHNOLOGY AND TARGETED DRUG DELIVERY
Abstract
Migration to the lesion is a fundamental property of stem cells of mammals. This property offers good prospects for their practical applications in oncology for targeted transport of drugs. The opportunity of purposeful migration into the area of glioma embryonic and adult neural stem cells, but their use is limited. With the practices of appropriate use hematopoietic stream cells. The aim of the work was to study the ability of the irtargeted migration to the site of an experimental glioma C6 line. Work carried out on Wistar rats, used neuroimaging, histological, immunohistochemical and immunofluorescence techniques. The results confirm the possibility of purposeful migration of hematopoietic stem cells to the site of glial brain tumors in experimental animals.
About the Authors
I. S. Bryukhovetskiy
A.V. Zhirmunsky Institute of Marine Biology of Far Eastern Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. S. Bryukhovetskiy
Clinics of interventional and restorative neurology and therapy “Neurovita”; Federal Research Centre of specialized types of medical care and technologies of the Federal Medical-Biological Agency of Russia
Russian Federation
Russian Federation
V. P. Chekhonin
P. Serbskii State Research Center for Social and Forensic Psychiatry of Ministry of Health of The Russian Federation
Russian Federation
Russian Federation
V. P. Baklaushev
P. Serbskii State Research Center for Social and Forensic Psychiatry of Ministry of Health of The Russian Federation
Russian Federation
Russian Federation
Yu. S. Khotimchenko
School of Biomedicine, Far Eastern Federal University
Russian Federation
Russian Federation
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Review
For citations:
Bryukhovetskiy I.S., Bryukhovetskiy A.S., Chekhonin V.P., Baklaushev V.P., Khotimchenko Yu.S. THE PHENOMENON OF DIRECTED MAMMALIAN STEM CELL MIGRATION TOWARD AN EXPERIMENTAL GLIOBLASTOMA SITE AS A BASIS OF INNOVATIVE ANTITUMOR TECHNOLOGY AND TARGETED DRUG DELIVERY. Pacific Medical Journal. 2013;(2):47-51. (In Russ.)
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