ESTIMATING DYNAMICS OF APOPTOSIS AND ITS REGULATION IN CASE OF MAXILLARY SINUS
Abstract
The paper overviews results of authors’ studies into molecular mechanisms of apoptosis and its role in reparation of mucous coat after deafferentation and mechanical injury of maxillary sinus. The progression of apoptosis, extent of production of nitric oxide, p53 and Bcl-2 in mucous cells appear to be interdependent. The nitric oxide is capable of showing proand anti-apoptogenic effects in different periods after injury. These processes result in the reduction of secondary injury of cells due to nitric oxide effects on apoptosis and stimulation of trophic and regeneration-related capabilities of the mucous coat. The inhibition of apoptosis can facilitate the regeneration processes. The stimulation of apoptosis in future may exhibit cytoprotective effects in case of secondary injury of inflammatory products
About the Authors
S. S. Edranov
Vladivostok State Medical University
Russian Federation
Russian Federation
V. G. Tsoy
Mobile Surgical Team Co Ltd
Russian Federation
Russian Federation
I. M. Kheteeva
Dental Clinic Almaz’
Russian Federation
Russian Federation
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Review
For citations:
Edranov S.S., Tsoy V.G., Kheteeva I.M. ESTIMATING DYNAMICS OF APOPTOSIS AND ITS REGULATION IN CASE OF MAXILLARY SINUS. Pacific Medical Journal. 2013;(1):12-15. (In Russ.)
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