The possibility of generation of secondary ionizing radiation on tantalum oxide nanoparticles in radiation therapy of malignant tumors
https://doi.org/10.17238/PmJ1609-1175.2016.4.38-40
Abstract
The administration of radiation sensitizer into a tumor succeeded by ray treatment leads to the additional secondary radiation inside the neoplasm that improves the effect of the ray treatment. Methods. Measuring the dose of ionizing radiation was conducted by using the phantom (WP 600). The 2.5 % suspension of nanoparticles (NPs) of tantalum oxide (Ta2O5) or control solution (0.9 % NaCl solution) were placed into a spherical sample. Dimensions of NPs were determined with the tool Zetasizer NanoZS and constituted 71±1 nm (А) и 81±1 nm (В). Со60 was used as a source of radiation. The measuring was carried out with the ionization chamber FC65-P, which recorded the total intensity of Y-radiation. The measuring was carried out at the open gate, the passage of Y-camera under the test specimen at a distance of 0.5 cm. Data were processed in Wolfram Mathematica 9.0. Results. The total radiation for samples containing NPs Ta2O5 was higher than those obtained in the measurement of ionizing radiation by a 0.9 % solution of NaCl. The increase for particles with a size of 65 nm was 5.5 % for particles with a size of 71 nm - 5.2 %, for a particle with a size of 81 nm - 7 %. The reason for increase in the emission intensity when passing hard Y-radiation through the low Ta2O5 is the generation of the secondary low-energy ionizing radiation. Conclusions. NPs Ta2O5 is a promising medicine for the treatment of local radio modification malignancies.
About the Authors
K. S. Lukyanenko
Far Eastern Federal University
Russian Federation
Russian Federation
V. I. Apanasevich
Pacific State Medical University; Regional Clinical Center of Specialized Medical Care
Russian Federation
Russian Federation
A. V. Lagureva
Pacific State Medical University
Russian Federation
Russian Federation
O. S. Plotnikova
Pacific State Medical University
Russian Federation
Russian Federation
I. V. Pankratov
Primorsky Regional Oncology Center
Russian Federation
Russian Federation
V. P. Rudyuk
Primorsky Regional Oncology Center
Russian Federation
Russian Federation
L. S. Stebunov
Primorsky Regional Oncology Center
Russian Federation
Russian Federation
A. A. Chernobaev
Primorsky Regional Oncology Center
Russian Federation
Russian Federation
P. A. Lykanov
G.B. Elyakov Pacific Institute of Bioorganic Chemistry FEB RAS
Russian Federation
Russian Federation
V. N. Davydova
G.B. Elyakov Pacific Institute of Bioorganic Chemistry FEB RAS
Russian Federation
Russian Federation
M. A. Medkov
Institute of Chemistry FEB RAS
Russian Federation
Russian Federation
V. N. Kustov
Vladivostok Branch of Russian Customs Academy (
Russian Federation
Russian Federation
V. V. Temchenko
Vladivostok Branch of Russian Customs Academy (
Russian Federation
Russian Federation
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Review
For citations:
Lukyanenko K.S., Apanasevich V.I., Lagureva A.V., Plotnikova O.S., Pankratov I.V., Rudyuk V.P., Stebunov L.S., Chernobaev A.A., Lykanov P.A., Davydova V.N., Medkov M.A., Kustov V.N., Temchenko V.V. The possibility of generation of secondary ionizing radiation on tantalum oxide nanoparticles in radiation therapy of malignant tumors. Pacific Medical Journal. 2016;61(4):38-39. (In Russ.) https://doi.org/10.17238/PmJ1609-1175.2016.4.38-40
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