Effects of Alpha lipoic acid on the state of cerebral microcirculatory bloodstream in case of experimental craniocerebral trauma in laboratory animals
Abstract
The experiment conducted on 62 laboratory rats with isolated severe traumatic brain injuries allowed to analyze the therapeutic efficiency of Alpha lipoic acid. The morphologic and neurovisual methods of investigation confirmed reduction in the cerebral tissue edema in the area where the secondary injury occurred. The authors believe the brain protective effects of the drug resulted from the nitric oxide-producing function of the brain microvessels.
About the Authors
A. V. Poleschuk
Vladivostok State Medical University
Russian Federation
Russian Federation
K. A. Drozdov
Pacific Institute of Bioorganic Chemistry
Russian Federation
Russian Federation
N. A. Andreeva
Vladivostok State Medical University
Russian Federation
Russian Federation
T. V. Balashova
Vladivostok State Medical University
Russian Federation
Russian Federation
V. V. Popova
Vladivostok State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Poleschuk A.V., Drozdov K.A., Andreeva N.A., Balashova T.V., Popova V.V. Effects of Alpha lipoic acid on the state of cerebral microcirculatory bloodstream in case of experimental craniocerebral trauma in laboratory animals. Pacific Medical Journal. 2012;(4):25-28. (In Russ.)
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