Role of matrix metalloproteinase-9 in diagnosing liver fibrosis in patients with chronic monoand mixed viral hepatitis
Abstract
The paper studies clinical, biochemical and virological parameters and immunological indicators of liver fibrosis in 120 patients with chronic viral hepatitis of different aetiology (B, C and mixed В+С, В+D, B+C+D). The mixed viral involvement caused more massive changes in the clinical picture of the disease. All the cases were characterized by the decrease in the matrix metalloproteinase-9 content in blood serum. Its deficit correlated with the progression of fibrotic changes in liver. Contrariwise, there was an increase in the protease with inhibitor level. The high indices were detected in case of viral hepatitis B of both mono- and mixed infections that could be explained by progressive fibrotic changes and marked cancer-causing potential of this pathogen. The authors indicate the direct dependence between the degree of viral load and degree of liver fibrosis.
About the Authors
V. A. Ivanis
Vladivostok State Medical University
Russian Federation
Russian Federation
E. A. Putilova
Vladivostok State Medical University
Russian Federation
Russian Federation
I. S. Gorelova
Vladivostok State Medical University
Russian Federation
Russian Federation
L. F. Sklyar
Vladivostok State Medical University
Russian Federation
Russian Federation
E. V. Markelova
Vladivostok State Medical University
Russian Federation
Russian Federation
References
1. Абдурахманов Д.Т. Перспективы в лечении хронического гепатита С//Клин. гепатология. 2010. № 3. С. 3-11.
2. Жебрун А.Б. Микробиология и иммунология, вызовы времени // Инфекция и иммунитет. 2011. Т. 1, № 1. С. 7-9.
3. Ивашкин В.Т. Иммунная система и повреждения печени при хронических гепатитах В и С // РЖГГК. 2009. № 6. С. 4-10.
4. Москалев А. В., Астапенко П.В., Рудой А. С. Неспецифическая диагностика латентных форм вирусных гепатитов В и С// Медицинская иммунология. 2011. Т. 13, № 4-5. С. 401.
5. Назаров П.Г. Реактанты острой фазы воспаления. СПб.: Наука, 2001. 423 с.
6. Клишо Е.В., Кондакова И.В., Чойнзонов Е.Л. Матриксные металлопротеиназы в онкогенезе // Сибирский онкологический журнал. 2003. № 2. С. 62-71.
7. Bataller R., Brenner D.A. Liver fibrosis // J. Clin. Invest. 2005. Vol. 115, No. 2. P. 209-218.
8. Benyon R.C., Iredate J.P. Is liver fibrosis reversible? // Gut. 2000. Vol. 46. P. 443-446.
9. Das S.K., Vasudevan D.M. Genesis of hepatic fibrosis and its biochemical markers // Scand. J. Clin. Lab. Invest. 2008. Vol. 4 (68). Р 260-269.
10. Marcellin P., Asselah N., Boyer N. Fibrosis and disease progression in hepatitis C // Hepatology. 2002. Vol. 1, No. 36. P. 47-56.
Review
For citations:
Ivanis V.A., Putilova E.A., Gorelova I.S., Sklyar L.F., Markelova E.V. Role of matrix metalloproteinase-9 in diagnosing liver fibrosis in patients with chronic monoand mixed viral hepatitis. Pacific Medical Journal. 2012;(4):74-77. (In Russ.)
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