Значение сероводорода в регуляции функций органов
Аннотация
В обзоре рассматриваются новые данные литературы и результаты собственных исследований по физиологии и патологии газотрансмиттера сероводорода. Сероводород синтезируется из цистеина с помощью пиридоксаль-5’-фосфат-зависимых ферментов цистатионин-р-синтазы или цистатионин-у-лиазы. Он стимулирует АТФ-зависимые калиевые каналы в гладкомышечных клетках сосудов, нейронах, кардиомиоцитах и β-клетках поджелудочной железы, участвуя в регуляции сосудистого тонуса, сокращении кардиомиоцитов, нейротрансмиссии и секреции инсулина. Рассматривается влияние сероводородпродуцирующих систем в патогенезе артериальной и легочной гипертензии, болезни Альцгеймера, циррозе печени.
Об авторах
А. А. Вараксин
Институт биологии моря им. А.В.Жирмунского ДВО РАН
Россия
Россия
Е. В. Пущина
Институт биологии моря им. А.В.Жирмунского ДВО РАН
Россия
Россия
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Рецензия
Для цитирования:
Вараксин А.А., Пущина Е.В. Значение сероводорода в регуляции функций органов. Тихоокеанский медицинский журнал. 2012;(2):27-36.
For citation:
Varaksin A.A., Puschina E.V. ROLE OF HYDROGEN SULPHIDE IN REGULATORY FUNCTIONS. Pacific Medical Journal. 2012;(2):27-36. (In Russ.)
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