Role of gram-negative bacteria in cytokine imbalance in case of pneumonia
Abstract
The rat-experiments allowed identifying differences between the levels of systemic and local cytokines and dynamics of their production, depending on the aetiology of pneumonia. Enterobacter-induced pneumonia was characterized by increasing systemic production of g-interferon and interleukin-10. In case of pneumonia caused by Escherichia coli, the level of interferon did not change; the level of interleukin-10 in blood serum was considerably lower than that of intact animals. The local level of cytokines in case of pneumonia caused by Enterobacter spp. was characterised by activation of interleukin-10 and suppression in production of g-interferon measured two weeks after infection. The growing local prevalence of interleukin-10 concentration was observed in case of mice infected with E. coli. Therefore, Enterobacter spp. and E. mli have evident immune-depressive effects on pulmonary defence factors required to be taken into account when choosing methods of pathogenetic therapy of nosocomial pneumonia.
About the Authors
A. V. Kostyushko
Vladivostok State Medical University; Medical and Diagnostic Center “Metchnikoff”, Vladivostok
Russian Federation
Russian Federation
N. M. Kondrashova
Vladivostok State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Kostyushko A.V., Kondrashova N.M. Role of gram-negative bacteria in cytokine imbalance in case of pneumonia. Pacific Medical Journal. 2011;(3):36-38. (In Russ.)
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