Summary - The review devoted to modern aspects of the education, scientific and clinical activity of the Vladivostok medical university. The modern administrative structure of high school is resulted; the review of the basic directions of scientific work and development of scientific schools is done. The pedagogical potential of university and its opportunity of introduction in educational and clinical process of innovative technologies are analyzed. Prospects of preparation of experts on under graduation and post graduation levels, including system of continuous profilization, through lyceum and special medical classes of schools of region are considered. The role of university is especially emphasized in realizations of the priority national project «Health». Key words: medical high school, educational, scientific and practical work, innovative technologies, the priority national project.
Pacific Medical Journal, 2008, No. 3, p. 6-11

In the article the achievements of employees of the department of the histology, studying during several decades the peripheral nervous system of brain and a spinal cord are stated. Intrabrain nerves and nervous cells of the intramedullar part of autonomic nervous system are described. Results of the hystophisiological researches of blood vessels are generalized, in which regulation neuromuscular, neuroparacrine and intimal mechanisms are found. The prolipheral potentions of the ependimal glia forming intraspine parts are investigated. The complex of organs based on ependimocytes is incorporated in cascade ependimo-adenomatous system of a brain.

Results of complex research of components of cytokine system at a system and local level at lung diseases (home, hospital pneumonia, tuberculosis) and at virus infections (hemorrhagic fever with nephritic syndrome, hepatitis C) are generalized and submitted It is shown, that early hyperproduction of the factor of the tumor necrosis and IL10 on a depression of markers of cell-dependent immune protection (IL2, γ-interferon) results in sharp increase of concentration of oxygen radicals and nitrogen oxide, promotes a prevalence of processes of the apoptosis on markers of cellular positive activation. It is the important pathogenetic part of adverse clinical presentation and the long follow-up. Proofs of influence of the activator of pneumonia on dynamics of the cytokine answer are received. Representations about the mechanisms of development of the immune deficit
conditions from a position of cytokine regulation are expanded.

The system of an estimation of an adaptable condition of the organism is created, allowing to formulate the general conclusion about levels of health of the human, and algorithm of effective correction of desadaptation by vegetable adaptogen (tinctures of the aralia, rodiola etc), dosed under individual plan, in view of style of self-control physiologic functional condition of an organism. Authors investigated individual physiologic features of students of various high schools of Vladivostok (medical, technological, marine university named by G.I.Nevelskoy) in dynamics of education.

Results of the ecologic and epidemiologic estimations of a geographic distribution of parameters of primary disease (incidence) and attributive risk of gastritis, duodenitis, ulcer disease, not infectious enteritis and colitis in Primorsky Krai for 15-year period of supervision are stated. Primary localization of the maximal values of primary disease and attributive risk of development of gastritis and duodenitis in rural areas with the most discomfort conditions for the population on a background of absence of the technogenic environmental contaminations is revealed.

Influence of the socio-biological factors on formation of the somatic vegetative dysfunction at 128 people and on frequency of mental infringements at 183 patients with a myocardial infarction and 111 patients with diabetes is investigated. Psycho-somatic frustration arose at patients with the reduced tolerance to psycho-trauma, caused by boundary mental frustration. In a clinical picture of the specified pathology there is the influence of psycho-trauma factors, premorbid features and degrees of expressiveness of somatic harm.

The mechanism of formation of infectious and not infectious pathology develops of interaction of three groups of factors: factors of pathogenicity, factors of the owner and factors of an inhabitancy. Thus the social and natural factors which are included in group of factors of an inhabitancy, realize an opportunity of interaction of factors of pathogenicity and factors of the owner and if it has already taken place - adjust the probable displays of epidemic process arising thereof interaction. Within this problem the features of epidemic process are opened for the hepatitis, HIV, tuberculosis, leptospirosis, pneumonias, sexual
transmitted diseases, and other infections in Primorsky Krai.

The paper presents the results comperative of the mixt-infection in children, as acute Ixodes viral encephalition with Ixodes Tick-borne Borreliosis (n=43) and infectious mononucleosis is the representative differente types of the Herpesviridae (n=38) and others ills, as mixt-infection by Epstein-Barr virus and acute viral hepatitis, listeriosis (n=22). It is shown, that Tick-borne mixt-infection provides without erythema migrans removed with fever, hepatomegalia and manifest as disease of the nervous system in varying degrees. An established mixt-forms infection by EBV was is causes fever, sore throat, hepatomegalia and enlarged lymph nodes

By Authors data about prevalence gastrointestinal diseases at children and teenagers of Vladivostok (a gastritis, a gastroduodenitis, a gastroesophageal reflux disease, a stomach ulcer) are presented. Growth of disease with the years is noted by increase in number of complications: at 73.5% children of 15-18 years with a stomach ulcer cicatricial deformation of a bulb of duodenum, at 3.0% bleeding and at 1.5% pylorostenosis was marked. Own experience shows, that 95% children with diseases of bodies of digestion can be surveyed and treated in a polyclinic. Early diagnostics of diseases gastroduodeonal zone at children and teenagers will promote decrease in their complications at adults, to decrease in disease by a stomach ulcer and a cancer of a stomach.

Experimental data about correction of consequences of an intensive electromagnetic irradiation which basically increases the tone of respiratory and vascular centers of a brain, arterial pressure, increases the working ability of heart and a level of a power exchange with the help of medicinal substances are resulted. As protectors of electromagnetic damages of embryos the substances participating in regulation of oxidizing processes, and preparations of anabolic type can be.

Opportunities of the computer electro-cardiotopography in diagnostics of chronic pulmonary heart and myocardium dystrophy of a right ventricle are considered. 63 patients with chronic obstructive lung disease of various degrees are surveyed. It is shown, that electro-cardiotopography with potentials from 260 removals considerably surpasses standard ECG and an echocardiography in sensitivity in diagnostics of myocardium dystrophy of a right ventricle. The most specific to this pathology are the changes of the bottom horizontal lines on the right cartogram, where T-inversion or its deepening on more than 3 mm is registered. Also the suggested method was more effective than ECG and echocardiography in diagnostics of chronic pulmonary heart.

Results of complex researches of central and hepatic hemodynamics are submitted at chronic heart insufficiency. At early stages of a syndrome the changes in contractility of myocardium are accompanied by decrease in the basic hemodynamic parameters, there is a decrease of the systolic blood inflow to liver and volume-velocity parameters; in IIA stage of chronic heart insufficiency venous stagnation appears. On initial start vaso-active systems (callicrein-kinine, simpatico-adrenal, rennin-angiotensin-aldosterone, biogenic amines) which regulate the hemodynamic condition Treatment at chronic heart insufficiency demand the hemodynamic parameters and a condition of vaso-active systems.

Physicians of the department of therapy No. 3 of the Vladivostok State Medical University together with acoustics, mathematicians and engineers for the first time on the Far East in 1988 had been started the research of acoustics of system of human breath, reproduction and updating of known methods of research and to creation of the equipment with unique diagnostic characteristics. In the article the result of joint research is done. The received results have allowed presenting to approbation three new methods of acoustic diagnostics of the lungs. For all these methods it was possible to allocate the objective acoustic attributes potentially possessing the diagnostic importance. As a whole, the results received during 20 years of research inspire optimism and allow to hope in the foreseeable future for introduction of the simple and completely harmless to the human acoustic technology of pulmonary diagnostics in practical public health.

The condition of vascular endothelium, its relaxing and constrictor reserves, inflammation markers and adipokines at 238 men with a metabolic syndrome and various forms of ischemic heart disease is investigated. The level of the nitrogen oxide metabolites, endothelin-1, C-reactive protein of blood, and also a condition of cytokine system on a level of IL 6, 10 and the factor of tumor necrosis and also adipokines - leptin and adiponectin was estimated. Changes of function in vascular endothelium which is shown by decrease in the level of the nitrogen oxide metabolites at a metabolic syndrome and increase of concentration of endothelin-1 at ischemic heart disease is established. C-reactive protein is raised already at a metabolic syndrome and even more grows at myocardial infarction. Dynamics in cytokines at myocardial infarction is characterized by decrease in the level of the tumor necrosis factor and IL10 and increase of the IL6. Concentration of leptin is raised at metabolic syndrome and at its combination to myocardial infarction whereas the level of adiponectin is reduced at adiponectin irrespective of presence of a metabolic syndrome.

The condensate of exhaled air is organ-specific liquid reflecting structural functional condition of the surfactant, its biogenic system and metabolic lung function. According to research of the condensate the parameters describing lipid, carbohydrates, fibers and minerals exchange in lungs in conditions of norm and pathology are received. It shows the profound patho-bio-chemical representations about metabolic processes in deep departments of respiratory system and their role in pathogenesis of lung diseases at action of adverse factors, search of markers for diagnostics, forecasting of diseases and toxic lung damage.

Inflammatory skin diseases of face, with defeat of the pilo-sebarrhea complex, cause active changes in the local and general immune status. Studying of immune and cytokine status at face dermatosis is one of the basic directions of scientific researches of the department dermatovenerology and medical cosmetology, together with the department of pathophysiology of the Vladivostok State Medical University. It is found, that inflammatory reaction at acne is supported by immune complex and cell types of immune reactions. Parasitic infections of skin cause depression of cell and humoral link of immunity. At rosazea the changes of humoral immunity prevail in particular the increase of a level of circulating immune complexes is observed. Changes of ratio of pro- and anti-inflammatory cytokine are found out at this pathology. The revealed changes cause necessity of the further studying and selection of the immune correcting medications.

As a result of teamwork of medical university and department of public health of Primorsky Krai the modern organizational and diagnostic technologies have been developed and introduced that has allowed to lower in 10 years the infantile death rate on 35.9%, dead birth - on 27.6% and early neonatal death rate - on 9.5%. Perinatal death rate has decreased from 17.4 (1993) up to 10.0‰ (2006). Results of joint research programs have give the positive contribution to process of reproduction of the population of Primorsky Krai, one of the reserves is decrease in a level of feto-infant losses.

The review devoted to results of the scientific activity of the department of regenerative medicine, manual medicine and reflexo-therapy of Vladivostok State Medical University. It is about achievements in non-medicamentous treatment of the vertebral and other painful syndromes, perinatal lesions of nervous system and motor problem at children, in rehabilitation of children, suffering by malignant diseases. Achievements are shown in the field of treatment and preventive maintenance of bone and muscular lesions, and nervous system at adults (students, sailors). The priorities facing to organizers of public health in the development of highly effective technologies of preservation of health of healthy, of diseases prophylaxis and rehabilitation of patients with use of non-medicamentous means and natural medical factors are formulated.

In the article the basic problems connected to use of medical products are stated, forms of post-graduation education on various sections of clinical pharmacology on the department of clinical pharmacology of Vladivostok State Medical University are submitted, and value of service of clinical pharmacology in optimization of use of medical products is shown.

The history of start and development of patho-anatomical service in Primorsky Krai is described in view of a role of the department of pathological anatomy of the Vladivostok medical university, ended by creation of the education-scientific-practical complex "Primorsky institute of regional pathology". The brief review of structure of death rate of the adult and children's population of Primorsky Krai and Vladivostok is given, the role of the iatrogenic pathologies in modern clinic is considered. The condition of quality assurance of lifetime diagnostics is analyzed depending on the form of the organization of patho-anatomical service. The basic problems are specified in lifetime and posthumous diagnostics of diseases, legal bases and ways of optimization of work of patho-anatomical service of region are considered.

In 2004 "Primorsky forensic medicine bureau" and faculties of forensic medicine of the Vladivostok state medical university created forensic expert-scientific and educational center which has united the best employees. Such connection of a science and practice has entitled to carry out major researches under orders of Russian Center of forensic medicine that has improved the of forensic medicine of sexual crimes and sexual conditions, has allowed to use morpho-hysto-chemical analysis of a structure of external genitals and their changes under influence of adverse factors. Employees of the Center participate in the international scientific programs, including on studying of Y-chromosome in a population of Primorsky Krai. Forensic examinations of defects of medical aid are done with the best representatives of the professors of VGMU and are simultaneously the manual for improvement of quality of medical help.

Results of the scientific work of faculty of pediatrics No. 1 VSMU are submitted. In teamwork with faculty of obstetrics and gynecology the criteria of an estimation of an intra-uterine condition of fetus with diagnostics of pathology in uterine-placenta systems have been developed. In a series of works the mechanisms of the pathogenesis of respiratory diseases and a condition of local immunity at term and prematurely born children are investigated. Epidemiological aspects and efficiency of reports of leukemia treatment were investigated, as well as lymphomas and anemia; questions of nephrology of children's age, a problem of heart pathologies, and a condition of reproductive health of teenagers were studied. Efficiency of results of the scientific work is shown by stabilization of parameters of health of the children's population in Primorsky Krai.

The basic directions of scientific activity of the department of microbiology, virology and the immunology within 49 years under the direction of the doctor of medical sciences, professor, member of the Russian Academy of Natural Sciences, PIMA, the honored physician of the Russian Federation N.S. Motavkina are generalized. Value of the basic scientific development, problems of immunology of drugs which was studied within last eight years is marked. Questions of ecology, an infectious pathology, immunology, genetics are in this scientific block. New directions of activity of the department, scientific unions with scientific institutions and practical public health are marked.

The review of results of scientific research of faculty of infectious diseases of the VGMU in more than 45 years. A leading scientific direction - perfection of diagnostics and therapy of the natural infections of Primorsky Krai. Last 10 years the research of the hemorrhagic fever with nephritic syndrome, chronic virus hepatitis, borelliosis, HIV-infection from positions of clinical infectious immunology and morphology are studied.

Anniversary review article, devoted to the life and activity of the outstanding scientist and physician V.S. Shapkin (1918-1998). The author - one of V.S. Shapkin's pupils - tells about his start as surgeon practitioner and the scientist who for the first time has developed the techniques of some difficult interventions in abdominal and thoracic surgery. The Vladivostok period of life of V.S. Shapkin, his scientific and practical work, and also the pedagogical activity which was come to the end with creation of scientific school of surgeons is shown in detail.